Evidence mapPaperPMID 34066713Full record

SynthesisCells2021

Angiogenic CD34 Stem Cell Therapy in Coronary Microvascular Repair-A Systematic Review.

Balaj Rai, Janki Shukla, Timothy D Henry, Odayme Quesada

Registry-linked trialOpen access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07604467 (Effects of CD34+ Stem Cells on Left Ventricular Dysfunction Among Patients With Takotsubo Syndrome), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07604467 recruitingnot on this map

Effects of CD34+ Stem Cells on Left Ventricular Dysfunction Among Patients With Takotsubo Syndrome

TypeobservationalSponsorUniversity Medical Centre LjubljanaRan2021 to 2026Enrolled40ConditionsTako Tsubo Cardiomyopathy, Microvascular Dysfunction, CD34+ Stem Cells, Heart Failure
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. CD34Histology and histopathology · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. INOCA/ANOCA: Mechanisms and novel treatments.American heart journal plus : cardiology research and practice · 2023
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. CD34Cellular and molecular life sciences : CMLS · 2022
    Article
  12. Review
  13. Contemporary Management of Refractory Angina.Interventional cardiology clinics · 2022
    Review
  14. Stem Cell Therapy Targets: Repêchage!Circulation research · 2022
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Balaj RaiLindner Center for Research, The Christ Hospital, Cincinnati, OH 45219, USA.
Janki ShuklaDepartment of Internal Medicine, University of Cincinnati Medical School, Cincinnati, OH 45219, USA.
Timothy D HenryLindner Center for Research, The Christ Hospital, Cincinnati, OH 45219, USA.
Odayme QuesadaLindner Center for Research, The Christ Hospital, Cincinnati, OH 45219, USA.
Christ Hospital · USLung Institute · USUniversity of Cincinnati · US

Funding

NIH HHS K23HL151867
6 · The paper itself

Abstract

Ischemia with non-obstructive coronary arteries (INOCA) is an increasingly recognized disease, with a prevalence of 3 to 4 million individuals, and is associated with a higher risk of morbidity, mortality, and a worse quality of life. Persistent angina in many patients with INOCA is due to coronary microvascular dysfunction (CMD), which can be difficult to diagnose and treat. A coronary flow reserve <2.5 is used to diagnose endothelial-independent CMD. Antianginal treatments are often ineffective in endothelial-independent CMD and thus novel treatment modalities are currently being studied for safety and efficacy. CD34

Indexed as

Neovascularization, PhysiologicStem CellsAntigens, CD34Cell- and Tissue-Based TherapyClinical Trials as TopicHumansIschemiaMicrovesselsStem Cell TransplantationAntigens, CD34CD34 stem cell therapycoronary microvascular dysfunctionischemia with non-obstructive coronary arteriesrefractory angina

Identifiers

PMID34066713
PMCPMC8151216
OpenAlexW3160756579

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.