Evidence map›Paper›PMID 34067156›Full record

ReviewInternational journal of molecular sciences2021

Extracellular Vesicles and Asthma-More Than Just a Co-Existence.

Bilal Alashkar Alhamwe, Daniel P Potaczek, Sarah Miethe, Fahd Alhamdan, Lukas Hintz, Arslan Magomedov, Holger Garn

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bilal Alashkar AlhamweInstitute of Tumor Immunology, Clinic for Hematology, Oncology and Immunology, Center for Tumor Biology and Immunology, Philipps University Marburg, 35043 Marburg, Germany.ORCID 0000-0002-7120-0013
Daniel P PotaczekTranslational Inflammation Research Division & Core Facility for Single Cell Multiomics, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center, Philipps University Marburg, 35043 Marburg, Germany.ORCID 0000-0003-0324-8506
Sarah MietheTranslational Inflammation Research Division & Core Facility for Single Cell Multiomics, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center, Philipps University Marburg, 35043 Marburg, Germany.
Fahd AlhamdanTranslational Inflammation Research Division & Core Facility for Single Cell Multiomics, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center, Philipps University Marburg, 35043 Marburg, Germany.
Lukas HintzTranslational Inflammation Research Division & Core Facility for Single Cell Multiomics, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center, Philipps University Marburg, 35043 Marburg, Germany.
Arslan MagomedovInstitute of Tumor Immunology, Clinic for Hematology, Oncology and Immunology, Center for Tumor Biology and Immunology, Philipps University Marburg, 35043 Marburg, Germany.
Holger GarnTranslational Inflammation Research Division & Core Facility for Single Cell Multiomics, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center, Philipps University Marburg, 35043 Marburg, Germany.ORCID 0000-0002-5178-4023

Funding

Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) 416910386 - GRK 2573/1Deutscher Akademischer Austauschdienst (DAAD) 91726294HessenFonds, World University Service (WUS), the Hessen State Ministry for Higher Education, Research and the Arts (HMWK) To F.A.
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are membranous structures, which are secreted by almost every cell type analyzed so far. In addition to their importance for cell-cell communication under physiological conditions, EVs are also released during pathogenesis and mechanistically contribute to this process. Here we summarize their functional relevance in asthma, one of the most common chronic non-communicable diseases. Asthma is a complex persistent inflammatory disorder of the airways characterized by reversible airflow obstruction and, from a long-term perspective, airway remodeling. Overall, mechanistic studies summarized here indicate the importance of different subtypes of EVs and their variable cargoes in the functioning of the pathways underlying asthma, and show some interesting potential for the development of future therapeutic interventions. Association studies in turn demonstrate a good diagnostic potential of EVs in asthma.

Indexed as

AnimalsAsthmaBiomarkersExtracellular VesiclesHumansMicroRNAsModels, BiologicalBiomarkersMicroRNAsairwayallergyasthmaepigenetic(-s)exosomeextracellular vesicle (EV)inflammationmicroRNA (miRNA)microvesicle (MV)

Identifiers

PMID34067156
PMCPMC8124625

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.