ArticleJournal of personalized medicine2021
Stromal Heterogeneity in the Human Proliferative Endometrium-A Single-Cell RNA Sequencing Study.
Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 66 citations in OpenAlex.
- The dual roles of uterine monocytes in regulation of tissue homeostasis throughout reproductive cycles in health and disease.Nature immunology · 2026Article
- Single-Cell RNA Sequencing Shows Markedly Elevated Immune Cell Proportions in the Endometrium of Women with Endometriosis-A Narrative Review.International journal of molecular sciences · 2026Review
- Molecular signature of human endometrial stem/progenitor cells at the single-cell level.Stem cell reports · 2026Article
- Review
- Distinct decidualization and senomorphic responses in endometrial vs. menstrual blood stem/stromal cells: implications for reproductive therapies.Stem cell research & therapy · 2026Article
- Cell Subtypes and Gene Dysfunction in Ovarian Endometriosis Before and After GnRHa Treatment Revealed by Single-Cell RNA Sequencing.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Unraveling the significance of decorin in endometriosis development through single cell sequencing and experimental approaches.PloS one · 2026Article
- A spatial transcriptomics dataset of the endometrium from repeated implantation failure patients.Scientific data · 2025Article
- Single-cell profiling of the human endometrium in polycystic ovary syndrome.Nature medicine · 2025Article
- Endometriosis and adenomyosis unveiled through single-cell glasses.American journal of obstetrics and gynecology · 2025Review
- Single-Cell RNA Sequencing of PBMCs Identified Junction Plakoglobin (JUP) as Stratification Biomarker for Endometriosis.International journal of molecular sciences · 2024Article
- Single-cell RNA sequencing reveals the differentiation and regulation of endplate cells in human intervertebral disc degeneration.Scientific reports · 2024Article
- Review
- An integrated single-cell reference atlas of the human endometrium.Nature genetics · 2024Article
- Endometriotic lesions exhibit distinct metabolic signature compared to paired eutopic endometrium at the single-cell level.Communications biology · 2024Article
- Article
- Restoration of functional endometrium in an intrauterine adhesion rat model with endometrial stromal cells transplantation.Stem cell research & therapy · 2024Article
- Article
- Single-cell RNA sequencing in endometrial cancer: exploring the epithelial cells and the microenvironment landscape.Frontiers in immunology · 2024Review
- Exploring distinct properties of endometrial stem cells through advanced single-cell analysis platforms.Stem cell research & therapy · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The endometrium undergoes regular regeneration and stromal proliferation as part of the normal menstrual cycle. To better understand cellular interactions driving the mechanisms in endometrial regeneration we employed single-cell RNA sequencing. Endometrial biopsies were obtained during the proliferative phase of the menstrual cycle from healthy fertile women and processed to single-cell suspensions which were submitted for sequencing. In addition to known endometrial cell types, bioinformatic analysis revealed multiple stromal populations suggestive of specific stromal niches with the ability to control inflammation and extracellular matrix composition. Ten different stromal cells and two pericyte subsets were identified. Applying different R packages (Seurat, SingleR, Velocyto) we established cell cluster diversity and cell lineage/trajectory, while using external data to validate our findings. By understanding healthy regeneration in the described stromal compartments, we aim to identify points of further investigation and possible targets for novel therapy development for benign gynecological disorders affecting endometrial regeneration and proliferation such as endometriosis and Asherman's syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.