Evidence map›Paper›PMID 34067375›Full record

ArticleCells2021

Generators of Pressure-Evoked Currents in Vertebrate Outer Retinal Neurons.

Ji-Jie Pang, Fan Gao, Samuel M Wu

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. The Variety of Mechanosensitive Ion Channels in Retinal Neurons.International journal of molecular sciences · 2024
    Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ji-Jie PangDepartment of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA.
Fan GaoDepartment of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA.
Samuel M WuDepartment of Ophthalmology, Baylor College of Medicine, Houston, TX 77030, USA.
Baylor College of Medicine · US

Funding

VISION RESEARCH CENTERP30EY002520 · NEI · BAYLOR COLLEGE OF MEDICINE · PI Samuel M Wu · 1985 to 2026
$14.8M
PHYSIOLOGY AND PHARMACOLOGY OF SYNAPSES IN THE RETINAR01EY004446 · NEI · BAYLOR COLLEGE OF MEDICINE · PI WU, SAMUEL M · 1985 to 2014
$5.4M
ROD AND CONE SIGNALING PATHWAYS IN MAMMALIAN RETINAR01EY019908 · NEI · BAYLOR COLLEGE OF MEDICINE · PI WU, SAMUEL M · 2010 to 2020
$3.8M
NEI NIH HHS P30 EY002520NEI NIH HHS R01 EY004446NEI NIH HHS R01 EY019908NIH HHS EY 004446, EY 019908, Vision Core EY 02520Research to prevent blindness Inc. (New York, NY) NARetinal research foundation (Houston, TX) NA
6 · The paper itself

Abstract

(1) Background: High-tension glaucoma damages the peripheral vision dominated by rods. How mechanosensitive channels (MSCs) in the outer retina mediate pressure responses is unclear. (2) Methods: Immunocytochemistry, patch clamp, and channel fluorescence were used to study MSCs in salamander photoreceptors. (3) Results: Immunoreactivity of transient receptor potential channel vanilloid 4 (TRPV4) was revealed in the outer plexiform layer, K

Indexed as

AnimalsCalciumMembrane PotentialsPhotoreceptor CellsRetinaRetinal NeuronsVertebratesVision, OcularCalciumconfocal microscopyimmunofluorescencemechanosensitive channelpatch clampingpotassium channelrodtemperatureTRPV

Identifiers

PMID34067375
PMCPMC8224636
OpenAlexW3164150705

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.