Evidence map›Paper›PMID 34068078›Full record

ArticleInternational journal of molecular sciences2021

MiR-15a-5p Confers Chemoresistance in Acute Myeloid Leukemia by Inhibiting Autophagy Induced by Daunorubicin.

Emeline Bollaert, Melissa Claus, Virginie Vandewalle, Sandrine Lenglez, Ahmed Essaghir, Jean-Baptiste Demoulin, Violaine Havelange

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Non-coding RNA research · 2025
    Article
  4. Article
  5. MircoRNAs predict and modulate responses to chemotherapy in leukemic patients.Naunyn-Schmiedeberg's archives of pharmacology · 2025
    Review
  6. Article
  7. Apelin/APJ: Another Player in the Cancer Biology Network.International journal of molecular sciences · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Complete miRNA-15/16 loss in mice promotes hematopoietic progenitor expansion and a myeloid-biased hyperproliferative state.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. The dual role of autophagy in acute myeloid leukemia.Journal of hematology & oncology · 2022
    Review
  20. MicroRNAs in Leukemias: A Clinically Annotated Compendium.International journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Emeline BollaertExperimental Medicine Unit, de Duve Institute, Université catholique de Louvain (UCLouvain), Avenue Hippocrate 75 box B1.74.05, 1200 Brussels, Belgium.
Melissa ClausExperimental Medicine Unit, de Duve Institute, Université catholique de Louvain (UCLouvain), Avenue Hippocrate 75 box B1.74.05, 1200 Brussels, Belgium.
Virginie VandewalleExperimental Medicine Unit, de Duve Institute, Université catholique de Louvain (UCLouvain), Avenue Hippocrate 75 box B1.74.05, 1200 Brussels, Belgium.
Sandrine LenglezExperimental Medicine Unit, de Duve Institute, Université catholique de Louvain (UCLouvain), Avenue Hippocrate 75 box B1.74.05, 1200 Brussels, Belgium.
Ahmed EssaghirExperimental Medicine Unit, de Duve Institute, Université catholique de Louvain (UCLouvain), Avenue Hippocrate 75 box B1.74.05, 1200 Brussels, Belgium.
Jean-Baptiste DemoulinExperimental Medicine Unit, de Duve Institute, Université catholique de Louvain (UCLouvain), Avenue Hippocrate 75 box B1.74.05, 1200 Brussels, Belgium.ORCID 0000-0002-8016-6689
Violaine HavelangeExperimental Medicine Unit, de Duve Institute, Université catholique de Louvain (UCLouvain), Avenue Hippocrate 75 box B1.74.05, 1200 Brussels, Belgium.ORCID 0000-0001-6061-6315
de Duve Institute · BECliniques Universitaires Saint-Luc · BE

Funding

Action de Recherche ConcertéeFNRSFondation contre le cancerFondation roi BaudouinFonds MaisinPlan Cancer Action#29Salus sanguinisTelevie (FNRS)
6 · The paper itself

Abstract

Anthracyclines remain a cornerstone of induction chemotherapy for acute myeloid leukemia (AML). Refractory or relapsed disease due to chemotherapy resistance is a major obstacle in AML management. MicroRNAs (miRNAs) have been observed to be involved in chemoresistance. We previously observed that

Indexed as

Gene Expression Regulation, NeoplasticAdultAntibiotics, AntineoplasticApoptosisAutophagyBiomarkers, TumorCell ProliferationDaunorubicinDrug Resistance, NeoplasmGene Expression ProfilingHumansLeukemia, Myeloid, AcuteMicroRNAsTumor Cells, CulturedAntibiotics, AntineoplasticBiomarkers, TumorDaunorubicinMicroRNAsMIRN15 microRNA, humanacute myeloid leukemiaautophagychemoresistancedaunorubicinmicroRNAtarget genes

Identifiers

PMID34068078
PMCPMC8152749
OpenAlexW3160735719

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.