Evidence map›Paper›PMID 34068508›Full record

ArticleInternational journal of molecular sciences2021

Dystrophin Deficiency Causes Progressive Depletion of Cardiovascular Progenitor Cells in the Heart.

Sarka Jelinkova, Yvonne Sleiman, Petr Fojtík, Franck Aimond, Amanda Finan, Gerald Hugon, Valerie Scheuermann, Deborah Beckerová, Olivier Cazorla, Marie Vincenti and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 2 countries.

Sarka JelinkovaDepartment of Biology, Faculty of Medicine, Masaryk University, Kamenice 5/A3, 62500 Brno, Czech Republic.ORCID 0000-0001-9385-4571
Yvonne SleimanPhyMedExp, University of Montpellier, INSERM, CNRS, 34295 Montpellier, France.ORCID 0000-0002-1550-8945
Petr FojtíkDepartment of Biology, Faculty of Medicine, Masaryk University, Kamenice 5/A3, 62500 Brno, Czech Republic.ORCID 0000-0003-0188-0022
Franck AimondPhyMedExp, University of Montpellier, INSERM, CNRS, 34295 Montpellier, France.
Amanda FinanPhyMedExp, University of Montpellier, INSERM, CNRS, 34295 Montpellier, France.
Gerald HugonPhyMedExp, University of Montpellier, INSERM, CNRS, 34295 Montpellier, France.
Valerie ScheuermannPhyMedExp, University of Montpellier, INSERM, CNRS, 34295 Montpellier, France.
Deborah BeckerováDepartment of Biology, Faculty of Medicine, Masaryk University, Kamenice 5/A3, 62500 Brno, Czech Republic.
Olivier CazorlaPhyMedExp, University of Montpellier, INSERM, CNRS, 34295 Montpellier, France.
Marie VincentiPhyMedExp, University of Montpellier, INSERM, CNRS, 34295 Montpellier, France.
Pascal AmedroPhyMedExp, University of Montpellier, INSERM, CNRS, 34295 Montpellier, France.
Sylvain RichardPhyMedExp, University of Montpellier, INSERM, CNRS, 34295 Montpellier, France.ORCID 0000-0001-9460-6705
Josef JarosICRC, St Anne's University Hospital, Pekařská 53, 65691 Brno, Czech Republic.
Petr DvorakDepartment of Biology, Faculty of Medicine, Masaryk University, Kamenice 5/A3, 62500 Brno, Czech Republic.
Alain LacampagnePhyMedExp, University of Montpellier, INSERM, CNRS, 34295 Montpellier, France.
Gilles CarnacPhyMedExp, University of Montpellier, INSERM, CNRS, 34295 Montpellier, France.
Vladimir RotreklDepartment of Biology, Faculty of Medicine, Masaryk University, Kamenice 5/A3, 62500 Brno, Czech Republic.ORCID 0000-0002-1298-0849
Albano C MeliPhyMedExp, University of Montpellier, INSERM, CNRS, 34295 Montpellier, France.ORCID 0000-0002-1727-3027
Centre National de la Recherche Scientifique · FRMasaryk University · CZ

Funding

Association Française contre les Myopathies 20225
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is a devastating condition shortening the lifespan of young men. DMD patients suffer from age-related dilated cardiomyopathy (DCM) that leads to heart failure. Several molecular mechanisms leading to cardiomyocyte death in DMD have been described. However, the pathological progression of DMD-associated DCM remains unclear. In skeletal muscle, a dramatic decrease in stem cells, so-called satellite cells, has been shown in DMD patients. Whether similar dysfunction occurs with cardiac muscle cardiovascular progenitor cells (CVPCs) in DMD remains to be explored. We hypothesized that the number of CVPCs decreases in the dystrophin-deficient heart with age and disease state, contributing to DCM progression. We used the dystrophin-deficient mouse model (

Indexed as

AgingAnimalsCardiomyopathy, DilatedCardiovascular SystemDisease Models, AnimalDNA DamageDystrophinGene Expression RegulationHumansMiceMice, Inbred mdxMuscular Dystrophy, DuchenneMyocardiumMyocytes, CardiacProto-Oncogene Proteins c-kitStem CellsDystrophinProto-Oncogene Proteins c-kitcardiovascular progenitorsc-kitdilated cardiomyopathyduchenne muscular dystrophygenomic instabilitymdx mouse

Identifiers

PMID34068508
PMCPMC8125982
OpenAlexW3163370135

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.