Differences in Somatic Mutation Profiles between Korean Gastric Cancer and Gastric Adenoma Patients.

Seung Woo Lee, Taekyu Lee, Hae Jung Sul, Ki Cheol Park, Joonhong Park

Abstract read

In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Seung Woo LeeDivision of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

Taekyu LeeThermo Fisher Scientific Solutions, Seoul 06349, Korea.

Hae Jung SulDepartment of Pathology, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.

Ki Cheol ParkClinical Research Institute, Daejeon St. Mary's Hospital, The Catholic University of Korea, Daejeon 34943, Korea.

Joonhong ParkDepartment of Laboratory Medicine, Jeonbuk National University Medical School and Hospital, Jeonju 54907, Korea.ORCID 0000-0001-7354-4234

Funding

clinical research institute grant funded by The Catholic University of Korea Daejeon St. Mary's Hospital CMCDJ-P-2019-017

6 · The paper itself

Abstract

backgroundWe aimed to investigate molecular factors potentially related to the progression of gastric adenoma (GA) to gastric cancer (GC) and compare the mutation characteristics between GC and GA.

methodsWe conducted custom gene panel sequencing for 135 GC-related genes and estimated the difference in somatic mutation profiles between 20 GC and 20 GA cases.

resultsA total of 31 somatic mutations, including 22 missense, 3 nonsense, and 6 frameshift mutations, were detected in 17 samples. We estimated an average of 1.8 mutations per sample (range, 1 to 3 mutations), with 12 in GC and 5 in GA. GC tended to have one or more mutated genes (

conclusionOur study demonstrates that the accumulation of mutant burden contributes to tumorigenesis progression from GA to GC in Korean patients, regardless of the kind of genes. These findings may elucidate the molecular pathogenesis of gastric carcinogenesis and malignant progression.

Indexed as

gastric adenomagastric cancermutant burdenmutation profilesnext-generation sequencing

Identifiers

PMID34068652

DOI10.3390/jcm10092038

PMCPMC8126162

What Socratic holds

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LicenceCC BY

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