Evidence map›Paper›PMID 34068759›Full record

ReviewMolecules (Basel, Switzerland)2021

Broad Applications of Thiazole Orange in Fluorescent Sensing of Biomolecules and Ions.

Ohad Suss, Leila Motiei, David Margulies

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Dissociation Constant (KSmall methods · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Design of synthetic peptide-based fluorescence probes for turn-on detection of hyaluronan.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ohad SussDepartment of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.ORCID 0000-0001-7377-1031
Leila MotieiDepartment of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.
David MarguliesDepartment of Chemical and Structural Biology, Weizmann Institute of Science, Rehovot 7610001, Israel.ORCID 0000-0002-8151-733X
Weizmann Institute of Science · IL

Funding

Dr. Barry Sherman Institute for Medicinal Chemistry 129130Israel Science Foundation 519/18
6 · The paper itself

Abstract

Fluorescent sensing of biomolecules has served as a revolutionary tool for studying and better understanding various biological systems. Therefore, it has become increasingly important to identify fluorescent building blocks that can be easily converted into sensing probes, which can detect specific targets with increasing sensitivity and accuracy. Over the past 30 years, thiazole orange (TO) has garnered great attention due to its low fluorescence background signal and remarkable 'turn-on' fluorescence response, being controlled only by its intramolecular torsional movement. These features have led to the development of numerous molecular probes that apply TO in order to sense a variety of biomolecules and metal ions. Here, we highlight the tremendous progress made in the field of TO-based sensors and demonstrate the different strategies that have enabled TO to evolve into a versatile dye for monitoring a collection of biomolecules.

Indexed as

BenzothiazolesDNAFluorescenceIonsMolecular ProbesProteinsQuinolinesBenzothiazolesDNAIonsMolecular ProbesProteinsQuinolinesthiazole orangefluorescent sensorsthiazole orangeturn-on sensors

Identifiers

PMID34068759
PMCPMC8126248
OpenAlexW3163101829

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.