ReviewInternational journal of molecular sciences2021
The Pathogenesis of Hydrocephalus Following Aneurysmal Subarachnoid Hemorrhage.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07662174 (VENTURE-PHH), which is not on this map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
VENTURE-PHH: Ventricular mTOR Inhibition to Prevent Hydrocephalus After Brain Hemorrhage
Who cites it
41 citing papers in PubMed, 77 citations in OpenAlex.
- Association of Impaired Hematoma Clearance After Aneurysmal Subarachnoid Hemorrhage with Delayed Cerebral Ischemia, Hydrocephalus, and Long-Term Outcomes.Neurocritical care · 2026Article
- Cerebrospinal Fluid Drainage Trajectories Are Associated With Ventriculoperitoneal Shunt Placement After Aneurysmal Subarachnoid Hemorrhage.Neurosurgery practice · 2026Article
- Inflammation Meets Ventricular Dynamics: Combined Hematologic and Radiologic Predictors of Shunt-Dependent Hydrocephalus in Endovascularly Treated Patients with Aneurysmal Subarachnoid Hemorrhage.Diagnostics (Basel, Switzerland) · 2026Article
- Subarachnoid Hemorrhage Causing Hydrocephalus: Narrative Review of a Neurosurgical Emergency.Cureus · 2026Review
- Article
- Brain Lymphatic Dysfunction in Subarachnoid Hemorrhage: Pathophysiology and Clinical Implications.Biomolecules · 2026Review
- Deep learning-assisted prediction of hydrocephalus in preoperative-subarachnoid hemorrhage: a multi-center study.Quantitative imaging in medicine and surgery · 2026Article
- Branch-Critical Clipping of a Ruptured Carotid-Posterior Communicating Aneurysm with Fetal PCA Configuration.Diagnostics (Basel, Switzerland) · 2026Article
- Impact of intracranial pressure and related parameters on prognosis in patients undergoing surgery for ruptured intracranial aneurysms.Neurosurgical review · 2025Article
- Mechanisms and interventions in aneurysmal subarachnoid hemorrhage: Unraveling the role of inflammatory responses and cell death in early brain injury (Review).Molecular medicine reports · 2025Review
- Prediction of functional outcomes in aneurysmal subarachnoid hemorrhage using pre-/postoperative noncontrast CT within 3 days of admission.NPJ digital medicine · 2025Article
- Constructing a nomogram for short-term prognosis in postoperative patients with aneurysmal subarachnoid hemorrhage: a two-center retrospective study.Scientific reports · 2025Article
- Post-traumatic hydrocephalus after decompressive craniectomy: a multidimensional analysis of clinical, radiological, and surgical risk factors.Neurosurgical review · 2025Article
- Meningeal lymphatic drainage: novel insights into central nervous system disease.Signal transduction and targeted therapy · 2025Review
- Microsurgical clipping remains a viable option for the treatment of coilable ruptured middle cerebral artery aneurysms in the endovascular era.Neurosurgical review · 2025Article
- White blood cells, monocytes and thrombin time in predicting symptomatic hydrocephalus in patients with aneurysmal subarachnoid hemorrhage.Frontiers in surgery · 2025Article
- Machine learning in developing a predictive model for chronic hydrocephalus following aneurysmal subarachnoid hemorrhage.Frontiers in neurology · 2025Article
- Navigating challenges in hydrocephalus following intraventricular hemorrhage: a comprehensive review of current evidence.Frontiers in neurology · 2025Review
- Mechanisms of hydrocephalus after intraventricular haemorrhage: a review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- Outcomes of Fenestration of Lamina Terminalis for Hydrocephalus following Clipping of Ruptured Aneurysms of Anterior Circulation.Pakistan journal of medical sciences · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrocephalus is a common complication of aneurysmal subarachnoid hemorrhage (aSAH) and reportedly contributes to poor neurological outcomes. In this review, we summarize the molecular and cellular mechanisms involved in the pathogenesis of hydrocephalus following aSAH and summarize its treatment strategies. Various mechanisms have been implicated for the development of chronic hydrocephalus following aSAH, including alterations in cerebral spinal fluid (CSF) dynamics, obstruction of the arachnoid granulations by blood products, and adhesions within the ventricular system. Regarding molecular mechanisms that cause chronic hydrocephalus following aSAH, we carried out an extensive review of animal studies and clinical trials about the transforming growth factor-β/SMAD signaling pathway, upregulation of tenascin-C, inflammation-dependent hypersecretion of CSF, systemic inflammatory response syndrome, and immune dysregulation. To identify the ideal treatment strategy, we discuss the predictive factors of shunt-dependent hydrocephalus between surgical clipping and endovascular coiling groups. The efficacy and safety of other surgical interventions including the endoscopic removal of an intraventricular hemorrhage, placement of an external ventricular drain, the use of intraventricular or cisternal fibrinolysis, and an endoscopic third ventriculostomy on shunt dependency following aSAH were also assessed. However, the optimal treatment is still controversial, and it necessitates further investigations. A better understanding of the pathogenesis of acute and chronic hydrocephalus following aSAH would facilitate the development of treatments and improve the outcome.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.