ReviewCancers2021
Epigenetic Effects of Benzene in Hematologic Neoplasms: The Altered Gene Expression.
Review in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Occupational benzene exposure and risk of kidney and bladder cancers: a systematic review and meta-analysis.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2025Pooled it
- Recent Advances in Biomonitoring of Gas Station Workers: A Systematic Review.Asian Pacific journal of cancer prevention : APJCP · 2024Pooled it
- Combined effects of thermal stress and benzene or toluene exposure on the immune and reproductive disruption in Nile tilapia (Oreochromis niloticus).Scientific reports · 2026Article
- Occupational benzene exposure and risk of lung cancer: a systematic review and meta-analysis.European journal of epidemiology · 2026Review
- Assessment of the carcinogenic potential of automotive gasoline in humans based on mechanistic evidence.Current research in toxicology · 2026Article
- Molecular mechanisms of air pollution-induced carcinogenesis and the emerging role of microplastics.Human genomics · 2025Review
- Testicular Tumors and Environmental Pollution: A Comparative Oncoepidemiology Study in the Campania Region from 2020 to 2023.Veterinary sciences · 2025Article
- Burden of hematologic malignancies in China from 1990 to 2021: analysis from the Global Burden of Disease Study 2021.BMC public health · 2025Article
- Hematological biochemical and liver function changes associated with BTEX exposure in a six year retrospective cohort study.Scientific reports · 2025Article
- Integrated Computational Analysis Reveals Early Genetic and Epigenetic AML Susceptibility Biomarkers in Benzene-Exposed Workers.International journal of molecular sciences · 2025Article
- Trends and Projections of Mortality Attributed to Occupational Neoplasms and Occupational Tracheal, Bronchus, and Lung Cancer in the World, G7 Countries and Turkey.Iranian journal of public health · 2024Article
- AI and ML-based risk assessment of chemicals: predicting carcinogenic risk from chemical-induced genomic instability.Frontiers in toxicology · 2024Review
- Coexistence ofTranslational cancer research · 2023Article
- Electrochemical and Optical Sensors for the Detection of Chemical Carcinogens Causing Leukemia.Sensors (Basel, Switzerland) · 2023Review
- Therapy-Related Myeloid Neoplasms: Predisposition and Clonal Evolution.Mediterranean journal of hematology and infectious diseases · 2023Review
- Effects of Benzene: Hematological and Hypersensitivity Manifestations in Resident Living in Oil Refinery Areas.Toxics · 2022Review
- Evaluating Phenotypic and Transcriptomic Responses Induced by Low-Level VOCs in Zebrafish: Benzene as an Example.Toxics · 2022Article
- Benzene exposure increases the risk of non-Hodgkin's lymphoma: a systematic review and meta-analysis of observational studies.Translational cancer research · 2022Article
- Multiple Myeloma: Challenges Encountered and Future Options for Better Treatment.International journal of molecular sciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Benzene carcinogenic ability has been reported, and chronic exposure to benzene can be one of the risk elements for solid cancers and hematological neoplasms. Benzene is acknowledged as a myelotoxin, and it is able to augment the risk for the onset of acute myeloid leukemia, myelodysplastic syndromes, aplastic anemia, and lymphomas. Possible mechanisms of benzene initiation of hematological tumors have been identified, as a genotoxic effect, an action on oxidative stress and inflammation and the provocation of immunosuppression. However, it is becoming evident that genetic alterations and the other causes are insufficient to fully justify several phenomena that influence the onset of hematologic malignancies. Acquired epigenetic alterations may participate with benzene leukemogenesis, as benzene may affect nuclear receptors, and provoke post-translational alterations at the protein level, thereby touching the function of regulatory proteins, comprising oncoproteins and tumor suppressor proteins. DNA hypomethylation correlates with stimulation of oncogenes, while the hypermethylation of CpG islands in promoter regions of specific tumor suppressor genes inhibits their transcription and stimulates the onset of tumors. The discovery of the systems of epigenetic induction of benzene-caused hematological tumors has allowed the possibility to operate with pharmacological interventions able of stopping or overturning the negative effects of benzene.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.