ArticleMolecules (Basel, Switzerland)2021
Anti-Melanogenic Properties of Velutin and Its Analogs.
Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 11 citations in OpenAlex.
- Phytochemistry and Biological Effects of theAntioxidants (Basel, Switzerland) · 2025Article
- Metabolic profiles and potential antioxidant mechanisms of hawk tea.Scientific reports · 2025Article
- Coumarins with Different Substituents fromInternational journal of molecular sciences · 2024Article
- Inhibition of Melanogenesis by Essential Oils from the Citrus Cultivars Peels.International journal of molecular sciences · 2023Article
- Chemical Composition of Leaves, Stem, and Roots ofMolecules (Basel, Switzerland) · 2022Article
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5 authors at 1 institution in 1 country.
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Abstract
Velutin, one of the flavones contained in natural plants, has various beneficial activities, such as skin whitening, as well as anti-inflammatory, anti-allergic, antioxidant, and antimicrobial activities. However, the relationship between the structure of velutin and its anti-melanogenesis activity is not yet investigated. In this study, we obtained 12 velutin derivatives substituted at C5, C7, C3', and C4' of the flavone backbone with hydrogen, hydroxyl, and methoxy functionalities by chemical synthesis, to perform SAR analysis of velutin structural analogues. The SAR study revealed that the substitution of functional groups at C5, C7, C3', and C4' of the flavone backbone affects biological activities related to melanin synthesis. The coexistence of hydroxyl and methoxy at the C5 and C7 position is essential for inhibiting tyrosinase activity. However, 1,2-diol compounds substituted at C3' and C4' of flavone backbone induce apoptosis of melanoma cells. Further, substitution at C3' and C4' with methoxy or hydrogen is essential for inhibiting melanogenesis. Thus, this study would be helpful for the development of natural-derived functional materials to regulate melanin synthesis.
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