Evidence map›Paper›PMID 34069836›Full record

ArticleAntioxidants (Basel, Switzerland)2021

Antioxidant Ascorbic Acid Modulates NLRP3 Inflammasome in LPS-G Treated Oral Stem Cells through NFκB/Caspase-1/IL-1β Pathway.

Jacopo Pizzicannella, Luigia Fonticoli, Simone Guarnieri, Guya D Marconi, Thangavelu Soundara Rajan, Oriana Trubiani, Francesca Diomede

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

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  12. A Phenolic-rich Extract of Cocoa (Frontiers in oral health · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jacopo Pizzicannella"Ss. Annunziata" Hospital, ASL 02 Lanciano-Vasto-Chieti, 66100 Chieti, Italy.
Luigia FonticoliDepartment of Innovative Technologies in Medicine & Dentistry, University "G. d'Annunzio" Chieti-Pescara, via dei Vestini, 31, 66100 Chieti, Italy.
Simone GuarnieriDepartment of Neuroscience, Imaging and Clinical Sciences, Center for Advanced Studies and Technology (CAST), University "G. d'Annunzio" Chieti-Pescara, via dei Vestini, 31, 66100 Chieti, Italy.ORCID 0000-0002-2916-2965
Guya D MarconiDepartment of Medical, Oral and Biotechnological Sciences, University "G. d'Annunzio" Chieti-Pescara, via dei Vestini, 31, 66100 Chieti, Italy.ORCID 0000-0001-7754-4653
Thangavelu Soundara RajanDepartment of Biotechnology, Karpagam Academy of Higher Education, Coimbatore 641 021, India.ORCID 0000-0001-8728-6176
Oriana TrubianiDepartment of Innovative Technologies in Medicine & Dentistry, University "G. d'Annunzio" Chieti-Pescara, via dei Vestini, 31, 66100 Chieti, Italy.ORCID 0000-0002-7459-4898
Francesca DiomedeDepartment of Innovative Technologies in Medicine & Dentistry, University "G. d'Annunzio" Chieti-Pescara, via dei Vestini, 31, 66100 Chieti, Italy.ORCID 0000-0002-0384-6509
University of Chieti-Pescara · ITKarpagam Academy of Higher Education · INOspedale SS. Annunziata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human gingival mesenchymal stem cells (hGMSCs) and endothelial committed hGMSCs (e-hGMSCs) have considerable potential to serve as an in vitro model to replicate the inflammation sustained by

Indexed as

ascorbic acidgingival mesenchymal stem cellsNLRP3 inflammasomeperiodontal diseasePorphyromonas gingivalis

Identifiers

PMID34069836
PMCPMC8157377
OpenAlexW3161798086

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.