Evidence map›Paper›PMID 34071460›Full record

ReviewInternational journal of molecular sciences2021

Mechanisms of Nausea and Vomiting: Current Knowledge and Recent Advances in Intracellular Emetic Signaling Systems.

Weixia Zhong, Omar Shahbaz, Garrett Teskey, Abrianna Beever, Nala Kachour, Vishwanath Venketaraman, Nissar A Darmani

Registry-linked trialOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06422793 (The Impact of Nasogastric Tube Gastric Decompression on Postoperative Nausea and Vomiting in Orthognathic Surgery), which is not on this map. Cited by 107 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
107citing papers in PubMed, 6 pooled it
27.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06422793 narecruitingnot on this mapstarted 2024, after this paper: background citation

The Impact of Nasogastric Tube Gastric Decompression on Postoperative Nausea and Vomiting in Orthognathic Surgery

TypeinterventionalSponsorNova Scotia Health AuthorityRan2024 to 2025Enrolled92ConditionsPostoperative Nausea, Postoperative VomitingArmsNo NG tube gastric decompression
3 · Its place in the literature

Who cites it

107 citing papers in PubMed, 6 syntheses or guidelines pooled it, 218 citations in OpenAlex.

  1. Pooled it
  2. Effect of ondansetron on QTc interval prolongation in healthy pediatric patients: a systematic review and meta-analysis.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2026
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47 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Weixia ZhongDepartment of Basic Medical Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, 309 East Second Street, Pomona, CA 91766, USA.
Omar ShahbazSchool of Medicine, Universidad Iberoamericana, Av. Francia 129, Santo Domingo 10203, Dominican Republic.
Garrett TeskeyDepartment of Basic Medical Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, 309 East Second Street, Pomona, CA 91766, USA.
Abrianna BeeverGraduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, USA.
Nala KachourGraduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, USA.
Vishwanath VenketaramanDepartment of Basic Medical Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, 309 East Second Street, Pomona, CA 91766, USA.ORCID 0000-0002-2586-1160
Nissar A DarmaniDepartment of Basic Medical Sciences, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, 309 East Second Street, Pomona, CA 91766, USA.ORCID 0000-0003-0028-099X
Western University of Health Sciences · USUniversidad Iberoamericana · DO

Funding

Development of SHP2 inhibitors for targeted anti-cancer therapyR01CA207288 · NCI · PURDUE UNIVERSITY · PI ZHANG, ZHONG-YIN · 2017 to 2021
$2.3M
Substance P tachykininergic NK1 receptor emetic signal transduction pathwaysR01CA207287 · NCI · WESTERN UNIVERSITY OF HEALTH SCIENCES · PI DARMANI, NISSAR A · 2017 to 2021
$1.5M
Glutathione depletion in the CNS and its effects on Mtb infectionR15HL143545 · NHLBI · WESTERN UNIVERSITY OF HEALTH SCIENCES · PI VENKETARAMAN, VISHWANATH · 2019 to 2024
$852k
NCI NIH HHS CA207288NCI NIH HHS R01 CA207287NHLBI NIH HHS R15 HL143545
6 · The paper itself

Abstract

Nausea and vomiting are common gastrointestinal complaints that can be triggered by diverse emetic stimuli through central and/or peripheral nervous systems. Both nausea and vomiting are considered as defense mechanisms when threatening toxins/drugs/bacteria/viruses/fungi enter the body either via the enteral (e.g., the gastrointestinal tract) or parenteral routes, including the blood, skin, and respiratory systems. While vomiting is the act of forceful removal of gastrointestinal contents, nausea is believed to be a subjective sensation that is more difficult to study in nonhuman species. In this review, the authors discuss the anatomical structures, neurotransmitters/mediators, and corresponding receptors, as well as intracellular emetic signaling pathways involved in the processes of nausea and vomiting in diverse animal models as well as humans. While blockade of emetic receptors in the prevention of vomiting is fairly well understood, the potential of new classes of antiemetics altering postreceptor signal transduction mechanisms is currently evolving, which is also reviewed. Finally, future directions within the field will be discussed in terms of important questions that remain to be resolved and advances in technology that may help provide potential answers.

Indexed as

AnimalsAntiemeticsEmeticsGastrointestinal TractHumansNauseaNeurotransmitter AgentsReceptors, Serotonin, 5-HT3Signal TransductionVomitingAntiemeticsEmeticsNeurotransmitter AgentsReceptors, Serotonin, 5-HT3brainstemCa2+emesisG-protein coupled receptorsnauseasignaling pathwaythe gastrointestinal tractvomiting

Identifiers

PMID34071460
PMCPMC8198651
OpenAlexW3165035209

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.