Evidence map›Paper›PMID 34072013›Full record

ArticleInternational journal of molecular sciences2021

Effect and Biocompatibility of a Cross-Linked Hyaluronic Acid and Polylactide-

Jung-Ah Cho, Bong-Jik Kim, Yu-Jung Hwang, Shin-Wook Woo, Tae-Soo Noh, Myung-Whan Suh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.0field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Glucocorticoid Effects on Proteoglycans and Glycosaminoglycans.International journal of molecular sciences · 2022
    Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jung-Ah ChoDepartment of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul 03080, Korea.
Bong-Jik KimDepartment of Otolaryngology-Head and Neck Surgery, College of Medicine, Chungnam National University, Daejeon 35015, Korea.
Yu-Jung HwangDepartment of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul 03080, Korea.
Shin-Wook WooDepartment of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul 03080, Korea.
Tae-Soo NohDepartment of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul 03080, Korea.
Myung-Whan SuhDepartment of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul 03080, Korea.
Seoul National University Hospital · KRChungnam National University · KR

Funding

National Research Foundation of Korea 2017R1C1B3005431
6 · The paper itself

Abstract

The treatment of acute hearing loss is clinically challenging due to the low efficacy of drug delivery into the inner ear. Local intratympanic administration of dexamethasone (D) and insulin-like growth factor 1 (IGF1) has been proposed for treatment, but they do not persist in the middle ear because they are typically delivered in fluid form. We developed a dual-vehicle drug delivery system consisting of cross-linked hyaluronic acid and polylactide-

Indexed as

Biocompatible MaterialsCapsulesAnimalsBiopsyCell CountDexamethasoneDisease Models, AnimalDrug CarriersDrug Delivery SystemsEndoscopyEvoked Potentials, Auditory, Brain StemHair Cells, Auditory, InnerHearing Loss, Noise-InducedHyaluronic AcidInjection, IntratympanicMiceBiocompatible MaterialsCapsulesDexamethasoneDrug CarriersHyaluronic AcidPolyglactin 910acute acoustic traumadexamethasonedrug deliveryhearing losshyaluronic acidmicrocapsule

Identifiers

PMID34072013
PMCPMC8198354
OpenAlexW3164559019

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.