Evidence map›Paper›PMID 34072104›Full record

ArticleInternational journal of molecular sciences2021

Pigmentation Levels Affect Melanoma Responses to

Małgorzata Pawlikowska, Tomasz Jędrzejewski, Andrzej T Slominski, Anna A Brożyna, Sylwia Wrotek

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. The small molecule ML233 is a direct inhibitor of tyrosinase function.bioRxiv : the preprint server for biology · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. COVID-19 and Cancer Diseases-The Potential ofInternational journal of molecular sciences · 2023
    Review
  12. Phytochemicals as Immunomodulatory Agents in Melanoma.International journal of molecular sciences · 2023
    Review
  13. Article
  14. Review
  15. Review
  16. Special Issue "Precision Oncology in Melanoma Progression".International journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Małgorzata PawlikowskaDepartment of Immunology, Faculty of Biology and Veterinary Sciences, Nicolaus Copernicus University, 87-100 Toruń, Poland.ORCID 0000-0002-0053-9124
Tomasz JędrzejewskiDepartment of Immunology, Faculty of Biology and Veterinary Sciences, Nicolaus Copernicus University, 87-100 Toruń, Poland.ORCID 0000-0001-8950-5643
Andrzej T SlominskiDepartment of Dermatology, Comprehensive Cancer Center, Cancer Chemoprevention Program, University of Alabama at Birmingham, Birmingham, AL 35294, USA.ORCID 0000-0001-8963-3995
Anna A BrożynaDepartment of Human Biology, Faculty of Biology and Veterinary Sciences, Nicolaus Copernicus University, 87-100 Toruń, Poland.ORCID 0000-0002-3195-9965
Sylwia WrotekDepartment of Immunology, Faculty of Biology and Veterinary Sciences, Nicolaus Copernicus University, 87-100 Toruń, Poland.
Nicolaus Copernicus University · PLUniversity of Alabama at Birmingham · US

Funding

Narodowe Centrum Nauki 2014/15/B/NZ4/00751
6 · The paper itself

Abstract

Melanoma, the malignancy originating from pigment-producing melanocytes, is the most aggressive form of skin cancer and has a poor prognosis once the disease starts to metastasize. The process of melanin synthesis generates an immunosuppressive and mutagenic environment, and can increase melanoma cell resistance to different treatment modalities, including chemo-, radio- or photodynamic therapy. Recently, we have shown that the presence of melanin pigment inhibits the melanoma cell response to bioactive components of

Indexed as

Skin PigmentationBiomarkersCell DeathCell Line, TumorCell SurvivalHumansLeukocytes, MononuclearMelaninsMelanocytesMelanomaNecroptosisPlant ExtractsPolyporaceaeReactive Oxygen SpeciesSignal TransductionBiomarkersMelaninsPlant ExtractsReactive Oxygen Speciesco-cultureCoriolus versicolor extractd-penicillaminekojic acidmelanogenesismelanomanecroptosispigmentationtherapy resistance

Identifiers

PMID34072104
PMCPMC8198516
OpenAlexW3164167859

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.