Evidence map›Paper›PMID 34072134›Full record

ReviewMolecules (Basel, Switzerland)2021

Fish and Shellfish-Derived Anti-Inflammatory Protein Products: Properties and Mechanisms.

David C Kemp, Jung Yeon Kwon

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 47 citations in OpenAlex.

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  14. Anti-inflammatory effects of fish bone fermented usingJournal of food science and technology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

David C KempDepartment of Food Science and Technology, Oregon State University, Corvallis, OR 97331, USA.
Jung Yeon KwonDepartment of Food Science and Technology, Oregon State University, Corvallis, OR 97331, USA.ORCID 0000-0002-5665-5028
Oregon State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The interest in utilizing food-derived compounds therapeutically has been rising. With the growing prevalence of systematic chronic inflammation (SCI), efforts to find treatments that do not result in the side effects of current anti-inflammatory drugs are underway. Bioactive peptides (BAPs) are a particularly promising class of compounds for the treatment of SCI, and the abundance of high-quality seafood processing byproducts (SPB) makes it a favorable material to derive anti-inflammatory BAPs. Recent research into the structural properties of anti-inflammatory BAPs has found a few key tendencies including they tend to be short and of low molecular weight (LMW), have an overall positive charge, contain hydrophobic amino acids (AAs), and be rich in radical scavenging AAs. SPB-derived anti-inflammatory BAPs have been observed to work via inhibition of the NF-κB and MAPK pathways by disrupting the phosphorylation of IκBα and one or more kinases (ERK, JNK, and p38), respectively. Radical scavenging capacity has also been shown to play a significant role in the efficacy of SPB-derived anti-inflammatory BAPs. To determine if SPB-derived BAPs can serve as an effective treatment for SCI it will be important to understand their properties and mechanisms of action, and this review highlights such findings in recent research.

Indexed as

Amino AcidsAnimalsAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalAntioxidantsDNA DamageExtracellular Signal-Regulated MAP KinasesFishesHydrophobic and Hydrophilic InteractionsInflammationMacrophagesMAP Kinase Kinase 4Molecular WeightNF-KappaB Inhibitor alphaOxidative Stressp38 Mitogen-Activated Protein KinasesAmino AcidsAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalAntioxidantsExtracellular Signal-Regulated MAP KinasesMAP Kinase Kinase 4NF-KappaB Inhibitor alphap38 Mitogen-Activated Protein KinasesPeptidesShellfish Proteinsanti-inflammatoryantioxidantbioactivehydrolysateinflammationmarinepeptidesseafood byproduct

Identifiers

PMID34072134
PMCPMC8198112
OpenAlexW3164944491

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.