Evidence map›Paper›PMID 34072293›Full record

Trial reportNutrients2021

Impact of Fatty Acid Supplementation on Cognitive Performance among United States (US) Military Officers: The Ranger Resilience and Improved Performance on Phospholipid-Bound Omega-3's (RRIPP-3) Study.

Bernadette P Marriott, Travis H Turner, Joseph R Hibbeln, Jill C Newman, Marcie Pregulman, Angela M Malek, Robert J Malcolm, Gregory A Burbelo, Jeffrey W Wismann

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  4. Trial
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  6. Review
  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Bernadette P MarriottDivision of Gastroenterology and Hepatology, Department of Medicine, College of Medicine, Medical University of South Carolina, 114 Doughty Street, Charleston, SC 29425, USA.
Travis H TurnerDepartment of Neurology, College of Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 301 CSB, Charleston, SC 29425, USA.
Joseph R HibbelnPsychiatry and Behavioral Health, Barton Health, 2209 Second Avenue, South Lake Tahoe, CA 96150, USA.
Jill C NewmanDivision of Gastroenterology and Hepatology, Department of Medicine, College of Medicine, Medical University of South Carolina, 114 Doughty Street, Charleston, SC 29425, USA.
Marcie PregulmanDivision of Nephrology, Department of Medicine, College of Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, CSB, HE814, MSC629, Charleston, SC 29425, USA.
Angela M MalekDepartment of Public Health Sciences, College of Medicine, Medical University of South Carolina, 135 Cannon Street, Suite 303C, Charleston, SC 29425, USA.ORCID 0000-0001-5691-5347
Robert J MalcolmDepartment of Psychiatry and Behavioral Sciences, College of Medicine, Medical University of South Carolina, 67 President Street, Charleston, SC 29425, USA.
Gregory A BurbeloLTC, Infantry, United States Army, 432 Lee Road.2069, Smiths Station, AL 36877, USA.
Jeffrey W WismannMajor, US Army Battalion Operations Officer, 4-23 Infantry Regiment, Joint Base Lewis-McChord, WA 98433, USA.
Medical University of South Carolina · USUnited States Army · USUnited States Department of the Army · US

Funding

Aker Biomarine Antartic AS award # 8B422-01
6 · The paper itself

Abstract

Studies have assessed omega-3 fatty acids and cognitive decline among older adults and cognitive development among children, although less is known about cognitive or neurological effects among young adults. We examined whether omega-3 supplementation from krill oil could improve cognition and resilience among young military officers compared to a control. This double-blind, placebo-controlled trial enrolled 555 officers (mean age 23.4 ± 2.8, 98.6% male) entering the United States (US) Army Infantry Basic Officer Leaders Course (IBOLC) with the intention to complete the US Ranger Course. Volunteer participants consumed eight dietary supplements daily of krill oil containing 2.3 g omega-3 or control (macadamia nut oil) over an approximate 20-week period. Cognitive functioning, resilience, and mood were assessed during a well-rested period at approximately 14 weeks and after a battlefield simulation at 16 weeks. Blood spot samples were collected to monitor compliance and dietary intake was assessed. All hypotheses were tested using both 'Intention to Treat' (ITT) and 'As Per Protocol' (APP) approaches. Of the 555 randomized individuals, 245 (44.1%) completed the study. No statistically significant group-by-time interactions indicating treatment effect were found on any outcomes. Poor compliance was indicated by lower than expected omega-3 elevations in the treatment group, and may have contributed to a failure to detect a response.

Indexed as

Dietary SupplementsResilience, PsychologicalAdultCognitionCognitive DysfunctionDouble-Blind MethodFatty Acids, Omega-3HumansMaleMilitary PersonnelNeuropsychological TestsPhospholipidsUnited StatesYoung AdultFatty Acids, Omega-3Phospholipidscognitive performancekrill oilmilitary officersomega-3 fatty acidsrandomized controlled trialUnited States

Identifiers

PMID34072293
PMCPMC8228047
OpenAlexW3164971398

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.