ArticleBMC psychiatry2021
Altered spontaneous neural activity in the precuneus, middle and superior frontal gyri, and hippocampus in college students with subclinical depression.
Article in BMC psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
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46 citing papers in PubMed, 3 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Exploration of brain imaging biomarkers in subthreshold depression patients across different ages: an ALE meta-analysis based on MRI studies.BMC psychiatry · 2025Pooled it
- Comparison of resting-state brain activity between insomnia and generalized anxiety disorder: A coordinate-based meta-analysis.Brain imaging and behavior · 2025Pooled it
- Structural and functional brain alterations in subthreshold depression: A multimodal coordinate-based meta-analysis.Human brain mapping · 2024Pooled it
- Dynamic Changes in ALFF and DC in Subthreshold Depression Before and After ICBT Intervention.Neuropsychiatric disease and treatment · 2025Trial
- Aberrant functional connectivity of the globus pallidus in the modulation of the relationship between childhood trauma and major depressive disorder.Journal of psychiatry & neuroscience : JPNTrial
- Discrimination of generalized anxiety and major depressive disorders by machine learning of resting-state functional MRI.BMC psychiatry · 2026Article
- Connectome-based growth models reveal individual heterogeneity and neurophysiological subtypes of subthreshold depression.Molecular psychiatry · 2026Article
- Altered Salience-Default Mode Network Dynamics in Subclinical Depression: A Preclustering-Based Co-Activation Pattern Analysis.CNS neuroscience & therapeutics · 2026Article
- Abnormal Activation and Connection in Middle Frontal Gyrus: A Potential Imaging Feature for Facial Synkinesis Comorbid Depression.Depression and anxiety · 2026Article
- A pilot study of inter-regional phase amplitude coupling as comorbid depression biomarker in temporal lobe epilepsy.Epilepsy & behavior : E&B · 2025Article
- A mega-analysis of low frequency resting-state measures in mood and psychosis-spectrum disorders.medRxiv : the preprint server for health sciences · 2025Article
- Serum sirtuin 3 levels and multimodal abnormalities in brain structure and function in Parkinson's disease patients with depression.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Neural Electrical Correlates of Subjective Happiness.Human brain mapping · 2025Article
- Degree centrality values in the left calcarine as a potential imaging biomarker for anxious major depressive disorder.World journal of psychiatry · 2025Article
- Disrupted small-world architecture and altered default mode network topology of brain functional network in college students with subclinical depression.BMC psychiatry · 2025Article
- Altered cerebral perfusion in Parkinson's disease patients with anxiety: an arterial spin labeling MRI study.Frontiers in neurology · 2025Article
- EEG microstate analysis between patients with major depressive disorder, subclinical depression, and healthy controls.Frontiers in psychiatry · 2025Article
- Abnormal stability of dynamic functional architecture in drug-naïve children with attention-deficit/hyperactivity disorder.BMC psychiatry · 2024Article
- Potassium channels in depression: emerging roles and potential targets.Cell & bioscience · 2024Review
- Aberrant brain network topology in youth with a familial risk for bipolar disorder: a task-based fMRI connectome study.Journal of child psychology and psychiatry, and allied disciplines · 2024Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSubclinical depression (ScD) is a prevalent condition associated with relatively mild depressive states, and it poses a high risk of developing into major depressive disorder (MDD). However, the neural pathology of ScD is still largely unknown. Identifying the spontaneous neural activity involved in ScD may help clarify risk factors for MDD and explore treatment strategies for mild stages of depression.
methodsA total of 34 ScD subjects and 40 age-, sex-, and education-matched healthy controls were screened from 1105 college students. The amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) of resting-state fMRI were calculated to reveal neural activity. Strict statistical strategies, including Gaussian random field (GRF), false discovery rate (FDR), and permutation test (PT) with threshold-free cluster enhancement (TFCE), were conducted. Based on the altered ALFF and ReHo, resting-state functional connectivity (RSFC) was further analyzed using a seed-based approach.
resultsThe right precuneus and left middle frontal gyrus (MFG) both showed significantly increased ALFF and ReHo in ScD subjects. Moreover, the left hippocampus and superior frontal gyrus (SFG) showed decreased ALFF and increased ReHo, respectively. In addition, ScD subjects showed increased RSFC between MFG and hippocampus compared to healthy controls, and significant positive correlation was found between the Beck Depression Inventory-II (BDI-II) score and RSFC from MFG to hippocampus in ScD group.
conclusionSpontaneous neural activities in the right precuneus, left MFG, SFG, and hippocampus were altered in ScD subjects. Functional alterations in these dorsolateral prefrontal cortex and default mode network regions are largely related to abnormal emotional processing in ScD, and indicate strong associations with brain impairments in MDD, which provide insight into potential pathophysiology mechanisms of subclinical depression.
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