Evidence map›Paper›PMID 34074800›Full record

ArticleAging2021

The dysregulated

Brad Ebanks, Thomas L Ingram, Gunjan Katyal, John R Ingram, Nicoleta Moisoi, Lisa Chakrabarti

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Frontiers in cell and developmental biology · 2022
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Brad EbanksSchool of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, LE12 5RD, UK.
Thomas L IngramSchool of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, LE12 5RD, UK.
Gunjan KatyalSchool of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, LE12 5RD, UK.
John R IngramSchool of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, LE12 5RD, UK.
Nicoleta MoisoiLeicester School of Pharmacy, Leicester Institute for Pharmaceutical Innovation, De Montfort University, The Gateway, Leicester LE1 9BH, UK.
Lisa ChakrabartiSchool of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, LE12 5RD, UK.
University of Nottingham · GBDe Montfort University · GB

Funding

Biotechnology and Biological Sciences Research Council BB/J014508/1
6 · The paper itself

Abstract

One of the genes which has been linked to the onset of juvenile/early onset Parkinson's disease (PD) is PINK1. There is evidence that supports the therapeutic potential of exercise in the alleviation of PD symptoms. It is possible that exercise may enhance synaptic plasticity, protect against neuro-inflammation and modulate L-Dopa regulated signalling pathways. We explored the effects of exercise on

Indexed as

Physical Conditioning, AnimalAnimalsDrosophila melanogasterDrosophila ProteinsElectrophoresis, Gel, Two-DimensionalEnergy MetabolismGene Expression RegulationGene OntologyMass SpectrometryMitochondriaMitochondrial ProteinsMolecular Sequence AnnotationMutationProtein Interaction MapsProtein Serine-Threonine KinasesProteomeDrosophila ProteinsMitochondrial ProteinsPINK1 protein, DrosophilaProtein Serine-Threonine KinasesProteomePTEN-Induced Putative KinaseDrosophilaexercisemitochondriaPINK1proteomics

Identifiers

PMID34074800
PMCPMC8221352
OpenAlexW3164649436

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.