Evidence map›Paper›PMID 34075130›Full record

Trial reportScientific reports2021

Insulin-mediated muscle microvascular perfusion and its phenotypic predictors in humans.

Kaitlin M Love, Linda A Jahn, Lee M Hartline, James T Patrie, Eugene J Barrett, Zhenqi Liu

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05478707 (Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05478707 phase2recruitingstarted 2023, after this paper: background citation

Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes

Ran2023Enrolled47Registered outcomes5Posted comparisons0ConditionsDiabetes Mellitus, Type 1, Endothelial DysfunctionArmsDulaglutide, Placebo
PMID 29310645PMID 24742660PMID 22732108PMID 27295427PMID 27436611PMID 27633186PMID 26082639PMID 11842075PMID 1348845PMID 15161743PMID 16109070PMID 16644702other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kaitlin M LoveDivision of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA.
Linda A JahnDivision of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA.
Lee M HartlineDivision of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA.
James T PatrieDepartment of Public Health Sciences, University of Virginia Health System, Charlottesville, VA, USA.
Eugene J BarrettDivision of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA.
Zhenqi LiuDivision of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, Charlottesville, VA, USA. zl3e@virginia.edu.

Funding

The integrated Translational Health Research Institute of Virginia (iTHRIV): Using Data to Improve HealthUL1TR003015 · NCATS · UNIVERSITY OF VIRGINIA · PI Donald E Brown, KAREN C. JOHNSTON · 2022 to 2023
$9.1M
Institutional Career Development CoreKL2TR003016 · NCATS · UNIVERSITY OF VIRGINIA · PI Jason Papin, BRADFORD B WORRALL · 2022 to 2023
$2.1M
Role of Microvascular insulin resistance and cardiorespiratory fitness in diabetesR01DK124344 · NIDDK · UNIVERSITY OF COLORADO DENVER · 2023 to 2025
$1.4M
Acute effects of hyperglycemia on heart and skeletal muscle microvasculatureR01HL142250 · NHLBI · UNIVERSITY OF VIRGINIA · PI EUGENE Joseph BARRETT · 2022 to 2022
$737k
Effects of Exercise and GLP-1R Agonism on Muscle Microvascular Perfusion and Insulin ActionR01DK125330 · UNIVERSITY OF VIRGINIA · 2025 to 2025
$657k
Interdisciplinary Training in Systems & Biomolecular Data ScienceT32GM145443 · UNIVERSITY OF VIRGINIA · 2025 to 2025
$321k
NCATS NIH HHS KL2 TR003016NCATS NIH HHS UL1 TR003015NHLBI NIH HHS R01 HL142250NIDDK NIH HHS F32 DK121431NIDDK NIH HHS R01 DK102359NIDDK NIH HHS R01 DK124344NIDDK NIH HHS R01 DK125330NIGMS NIH HHS T32 GM145443NIH HHS R01DK102359NIH HHS R01DK125330
6 · The paper itself

Abstract

Insulin increases muscle microvascular perfusion and enhances tissue insulin and nutrient delivery. Our aim was to determine phenotypic traits that foretell human muscle microvascular insulin responses. Hyperinsulinemic euglycemic clamps were performed in 97 adult humans who were lean and healthy, had class 1 obesity without comorbidities, or controlled type 1 diabetes without complications. Insulin-mediated whole-body glucose disposal rates (M-value) and insulin-induced changes in muscle microvascular blood volume (ΔMBV) were determined. Univariate and multivariate analyses were conducted to examine bivariate and multivariate relationships between outcomes, ΔMBV and M-value, and predictor variables, body mass index (BMI), total body weight (WT), percent body fat (BF), lean body mass, blood pressure, maximum consumption of oxygen (VO

Indexed as

Insulin ResistanceModels, CardiovascularMuscle, SkeletalAdolescentAdultBlood VolumeFemaleGlucose Clamp TechniqueHumansInsulinMaleMicrocirculationMicrovesselsMiddle AgedInsulin

Identifiers

PMID34075130
PMCPMC8169863

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.