Observational studyJournal of diabetes investigation2021
Effect of glycemic gap upon mortality in critically ill patients with diabetes.
Observational study in Journal of diabetes investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Association of the blood glucose-to-platelet ratio with all-cause mortality in diabetic patients: An analysis of the MIMIC-IV database.Medicine · 2026Article
- Risk Factors for Mortality in Critically Ill Patients with Diabetes Admitted to the ICU: A Single-Center Retrospective Observational Study.Journal of clinical medicine · 2026Article
- Prognostic value of glycemic gap in ST-segment elevation myocardial infarction-associated acute kidney injury.BMC nephrology · 2025Article
- The Value of Glycemic Gap for Predicting Mortality in ICU in Patients With and Without Diabetes.Journal of diabetes research · 2025Article
- Time-Lagged Effects of Hyperglycemia on Inflammation in Older Adults with Community-Acquired Pneumonia: Nutritional Insights and Personalized Intervention Windows.Clinical interventions in aging · 2025Article
- Comparison of below-knee and above-knee amputations with demographic, comorbidity, and haematological parameters in patients who died.Journal of foot and ankle research · 2023Article
- Potentially inappropriate medications with older people in intensive care and associated factors: a historic cohort study.Sao Paulo medical journal = Revista paulista de medicina · 2023Article
- Association between dysglycemia and mortality by diabetes status and risk factors of dysglycemia in critically ill patients: a retrospective study.Acta diabetologica · 2022Article
- Novel Glycemic Index Based on Continuous Glucose Monitoring to Predict Poor Clinical Outcomes in Critically Ill Patients: A Pilot Study.Frontiers in endocrinology · 2022Article
- Effect of glycemic gap upon mortality in critically ill patients with diabetes.Journal of diabetes investigation · 2021Observational
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
AIMS/
introductionHyperglycemia, hypoglycemia, and blood glucose fluctuation are associated with the outcome in critically ill patients, but the target of blood glucose control is debatable especially in patients with diabetes regarding the status of blood glucose control before admission to ICU. This study aimed to investigate the association between the glycemic gap which is calculated as the mean blood glucose level during the first 7 days after admission to ICU minus the A1C-derived average glucose and the outcome of critically ill patients with diabetes.
methodThis study was undertaken in two intensive care units (ICUs) with a total of 30 beds. Patients with diabetes who were expected to stay for more than 24 h were enrolled, the HbA1c was tested within 3 days after admission and converted to the A1C-derived average glucose (ADAG) by the equation: ADAG = [(HbA1c * 28.7) - 46.7 ] * 18
resultsFive hundred and two patients were enrolled and divided into a survival group (n = 310) and a nonsurvival group (n = 192). It was shown that the two groups had a comparable level of HbA1c, the nonsurvivors had a greater APACHE II, MGL, SD, CV, GAP
conclusionsGlycemic GAP between the mean level of blood glucose within the first 7 days after admission to ICU and the A1C-derived average glucose was independently associated with a 28 day mortality of critically ill patients with diabetes, the predictive power extended to 1 year. The incidence of hypoglycemia was associated with mortality either.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.