Evidence map›Paper›PMID 34075742›Full record

ArticleAnalytical chemistry2021

Successive High-Resolution (H

Hua Tian, Louis J Sparvero, Tamil Selvan Anthonymuthu, Wan-Yang Sun, Andrew A Amoscato, Rong-Rong He, Hülya Bayır, Valerian E Kagan, Nicholas Winograd

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Emerging Roles of Ferroptosis in Skin Pathophysiology.The Journal of investigative dermatology · 2025
    Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Mass Spectrometry Imaging.Analytical chemistry · 2025
    Review
  14. Article
  15. Review
  16. Review
  17. Spatial Proteomics towards cellular Resolution.Expert review of proteomics · 2024
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Hua TianDepartment of Chemistry, Pennsylvania State University, Chemistry Building, Shortlidge Rd, University Park, Pennsylvania 16802, United States.ORCID 0000-0002-3598-0219
Louis J SparveroDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, PUBHL A-420, 130 DeSoto Street, Pittsburgh, Pennsylvania 15261, United States.ORCID 0000-0001-6347-8448
Tamil Selvan AnthonymuthuDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, PUBHL A-420, 130 DeSoto Street, Pittsburgh, Pennsylvania 15261, United States.ORCID 0000-0002-3460-5003
Wan-Yang SunCollege of Pharmacy, Jinan University, 601 Huangpu W Avenue, Guangzhou, Guangdong 510632, P. R. China.
Andrew A AmoscatoDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, PUBHL A-420, 130 DeSoto Street, Pittsburgh, Pennsylvania 15261, United States.
Rong-Rong HeCollege of Pharmacy, Jinan University, 601 Huangpu W Avenue, Guangzhou, Guangdong 510632, P. R. China.
Hülya BayırDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, PUBHL A-420, 130 DeSoto Street, Pittsburgh, Pennsylvania 15261, United States.ORCID 0000-0003-2361-4120
Valerian E KaganDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health, University of Pittsburgh, PUBHL A-420, 130 DeSoto Street, Pittsburgh, Pennsylvania 15261, United States.ORCID 0000-0002-7245-1885
Nicholas WinogradDepartment of Chemistry, Pennsylvania State University, Chemistry Building, Shortlidge Rd, University Park, Pennsylvania 16802, United States.
University of Pittsburgh · USJinan University · CNPennsylvania State University · US

Funding

Regulation of Cardiolin Byosynthesis in Epithelial InjuryP01HL114453 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2014 to 2023
$21.3M
Mapping Lipid Oxidation in Traumatic Brain Injury by Mass Spectrometric ImagingR01NS076511 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Hülya Bayir, Valerian E Kagan · 2012 to 2026
$6.8M
Lipids and Myeloid Cell Function in CancerR01CA165065 · NCI · WISTAR INSTITUTE · PI KAGAN, VALERIAN E, MONTANER, LUIS J · 2012 to 2022
$3.8M
Oxidative Lipidomics in Pediatric Traumatic Brain InjuryR01NS061817 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAYIR, HÜLYA · 2008 to 2018
$3.3M
Protein-Oxidized Phospholipid Interactions Determine Epithelial Cell Fate and Asthma Control  R01AI145406 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sally E Wenzel · 2020 to 2026
$2.9M
Radiation Mitigators Targeting Regulated Necrosis Pathways of Parthanatos PyroptosisU01AI156923 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAYIR, HÜLYA · 2020 to 2024
$2.4M
Selective Inhibitors of Pro-Ferroptotic Lipoxygenases - Next Generation RadiomitigatorsU01AI156924 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAGAN, VALERIAN E · 2020 to 2024
$2.3M
Oxidative Lipidomics in Pediatric Traumatic Brain InjuryR37NS061817 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Hülya Bayir · 2021 to 2026
$2.2M
Molecular Imaging of Biomaterials - Single CellsR01GM113746 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI WINOGRAD, NICHOLAS · 2014 to 2017
$1.7M
The molecular basis of cardiolipin-protein interactions implicated in intrinsic apoptosisR01GM113908 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAGAN, VALERIAN E · 2016 to 2019
$1.5M
Controlling monolysocardiolipin/cytochrome c peroxidase complexes in Barth syndromeR01GM134715 · NIGMS · WAYNE STATE UNIVERSITY · PI GREENBERG, MIRIAM L · 2020 to 2021
$842k
Multimodal mass spectrometry imaging of mouse and human liverUG3CA256962 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI STOCKWELL, BRENT R., TIAN, HUA · 2020 to 2021
$600k
NCI NIH HHS R01 CA165065NCI NIH HHS UG3 CA256962NHLBI NIH HHS P01 HL114453NIAID NIH HHS R01 AI145406NIAID NIH HHS U01 AI156923NIAID NIH HHS U01 AI156924NIGMS NIH HHS R01 GM113746NIGMS NIH HHS R01 GM113908NIGMS NIH HHS R01 GM134715NINDS NIH HHS R01 NS061817NINDS NIH HHS R01 NS076511NINDS NIH HHS R37 NS061817
6 · The paper itself

Abstract

The temporo-spatial organization of different cells in the tumor microenvironment (TME) is the key to understanding their complex communication networks and the immune landscape that exists within compromised tissues. Multi-omics profiling of single-interacting cells in the native TME is critical for providing further information regarding the reprograming mechanisms leading to immunosuppression and tumor progression. This requires new technologies for biomolecular profiling of phenotypically heterogeneous cells on the same tissue sample. Here, we developed a new methodology for comprehensive lipidomic and metabolomic profiling of individual cells on frozen-hydrated tissue sections using water gas cluster ion beam secondary ion mass spectrometry ((H

Indexed as

Breast NeoplasmsFemaleHumansIonsLipidsSpectrometry, Mass, Secondary IonTumor MicroenvironmentIonsLipids

Identifiers

PMID34075742
PMCPMC8209780
OpenAlexW3165560658

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.