Antihypertensives × blood pressure

TrialJAMA cardiology2021

Effect of the Million Hearts Cardiovascular Disease Risk Reduction Model on Initiating and Intensifying Medications: A Prespecified Secondary Analysis of a Randomized Clinical Trial.

G Greg Peterson et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedrandomised · 2021

Randomised comparison

Probably raised blood pressure

+4.80+2.90 to +6.70

As reported

difference 4.8, 95% CI 2.90–6.70

Randomised comparison

Probably lowered lipids

−1.80−2.90 to −0.60

As reported

difference −1.8, 95% CI −2.90 to −0.60

Randomised comparison

Probably lowered blood pressure

−1.70−2.80 to −0.60

As reported

difference −1.7, 95% CI −2.80 to −0.60

Three numbers in the abstract

the abstract, start to end

difference in percentage points, 4.8; 95% CI, 2.9-6.7; P < .001) to

difference in percentage points, -1.8; 95% CI, -2.9 to -0.6; P = .002), as was systolic blood pressure (mean [SD], 133 [15.7] vs 135 [16.4] mm Hg; adjusted difference in percentage points, -1.7; 95% CI, -2.8 to -0.6;

← favours treatmentfavours comparator →
could be chance
Blood pressure
4.82.90–6.70
Lipids
−1.8−2.90 to −0.60
Blood pressure
−1.7−2.80 to −0.60
AntihypertensivesLipidsBlood pressure

Antihypertensives × blood pressurehelps?replicated

unlikelylikely
0.960.50 without it

Antihypertensives × lipidshelps?replicated

unlikelylikely
0.960.50 without it
← favours treatmentfavours comparator →
this papermore certainless certain
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11 papers cite it

2021
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Full record →Abstract, authors, funding and every citing paper · PMID 34076665