ArticleCardiovascular engineering and technology2022
Development of Custom Wall-Less Cardiovascular Flow Phantoms with Tissue-Mimicking Gel.
Article in Cardiovascular engineering and technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Roadmap for light interaction with biophotonic surfaces and their diverse applications.Journal of biomedical optics · 2026Article
- Development and Characteristics of a Dual-Layered Vascular Phantom.Cardiovascular engineering and technology · 2026Article
- Scalable DICOM 3D-printed phantoms mimicking marine mammal bone and soft tissue.Scientific reports · 2026Article
- Experimental and computational models for intracardiac flow analysis with blood speckle imaging.PloS one · 2026Article
- Development of breast-mimicking phantoms for use in optical coherence elastography.Journal of biomedical optics · 2025Article
- Design and fabrication of a parasite-inspired, millimeter-scale tissue anchoring mechanism.PNAS nexus · 2024Article
- Customizable Angioplasty Balloon-Forming Machine: Towards Precision Medicine in Coronary Bifurcation Lesion Interventions.Journal of cardiovascular translational research · 2022Article
- Mechanical Characterization of Synthetic Gels for Creation of Surrogate Hands Subjected to Low-Velocity Impacts.Gels (Basel, Switzerland) · 2022Article
- In Vitro Blood Clot Formation and Dissolution for Testing New Stroke-Treatment Devices.Biomedicines · 2022Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeFlow phantoms are used in experimental settings to aid in the simulation of blood flow. Custom geometries are available, but current phantom materials present issues with degradability and/or mimicking the mechanical properties of human tissue. In this study, a method of fabricating custom wall-less flow phantoms from a tissue-mimicking gel using 3D printed inserts is developed.
methodsA 3D blood vessel geometry example of a bifurcated artery model was 3D printed in polyvinyl alcohol, embedded in tissue-mimicking gel, and subsequently dissolved to create a phantom. Uniaxial compression testing was performed to determine the Young's moduli of the five gel types. Angle-independent, ultrasound-based imaging modalities, Vector Flow Imaging (VFI) and Blood Speckle Imaging (BSI), were utilized for flow visualization of a straight channel phantom.
resultsA wall-less phantom of the bifurcated artery was fabricated with minimal bubbles and continuous flow demonstrated. Additionally, flow was visualized through a straight channel phantom by VFI and BSI. The available gel types are suitable for mimicking a variety of tissue types, including cardiac tissue and blood vessels.
conclusionCustom, tissue-mimicking flow phantoms can be fabricated using the developed methodology and have potential for use in a variety of applications, including ultrasound-based imaging methods. This is the first reported use of BSI with an in vitro flow phantom.
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