Evidence map›Paper›PMID 34082061›Full record

ReviewNeurochemistry international2021

piRNAs and endo-siRNAs: Small molecules with large roles in the nervous system.

Maria C Ow, Sarah E Hall

Open access · greenAbstract readReview
In one paragraph

Review in Neurochemistry international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Maria C OwBiology Department, Syracuse University, 107 College Place, Syracuse, NY, 13244, USA. Electronic address: mcow@syr.edu.
Sarah E HallBiology Department, Syracuse University, 107 College Place, Syracuse, NY, 13244, USA. Electronic address: shall@syr.edu.
Syracuse University · US

Funding

Characterization of endocrine signaling and RNAi pathways as mechanisms regulating environmental programming in C. elegansR01GM129135 · NIGMS · SYRACUSE UNIVERSITY · PI HALL, SARAH E · 2019 to 2023
$1.5M
NIGMS NIH HHS R01 GM129135
6 · The paper itself

Abstract

Since their discovery, small non-coding RNAs have emerged as powerhouses in the regulation of numerous cellular processes. In addition to guarding the integrity of the reproductive system, small non-coding RNAs play critical roles in the maintenance of the soma. Accumulating evidence indicates that small non-coding RNAs perform vital functions in the animal nervous system such as restricting the activity of deleterious transposable elements, regulating nerve regeneration, and mediating learning and memory. In this review, we provide an overview of the current understanding of the contribution of two major classes of small non-coding RNAs, piRNAs and endo-siRNAs, to the nervous system development and function, and present highlights on how the dysregulation of small non-coding RNA pathways can assist in understanding the neuropathology of human neurological disorders.

Indexed as

AnimalsHumansNervous System DiseasesNervous System Physiological PhenomenaRNA InterferenceRNA, Small InterferingRNA, Small InterferingArgonauteendo-siRNAneuronpiRNAPIWIRNAi

Identifiers

PMID34082061
PMCPMC8286337
OpenAlexW3164619335

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.