Evidence map›Paper›PMID 34083496›Full record

ArticleAging2021

Prevalence of proliferating CD8

Niclas C Blessin, Raed Abu-Hashem, Tim Mandelkow, Wenchao Li, Ronald Simon, Claudia Hube-Magg, Christina Möller-Koop, Melanie Witt, Alice Schmidt, Franziska Büscheck and 15 more

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Unraveling the Effects and Characteristics of Proliferating Tumor and Cytotoxic T Cells in Colorectal Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  4. Article
  5. Menstrual Effluent Derived Immune Cell Composition Is Distinct in Women Using Contraceptives: A Pilot Study.American journal of reproductive immunology (New York, N.Y. : 1989) · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Prognostic role of proliferating CD8Cellular oncology (Dordrecht, Netherlands) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 2 institutions in 1 country.

Niclas C BlessinInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Raed Abu-HashemInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Tim MandelkowInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Wenchao LiInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Ronald SimonInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Claudia Hube-MaggInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Christina Möller-KoopInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Melanie WittInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Alice SchmidtInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Franziska BüscheckInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Christoph FrauneInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Andreas M LuebkeInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Katharina MöllerInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Frank JacobsenInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Florian LutzInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Maximilian LennartzInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Stefan SteurerInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Guido SauterInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Doris HöflmayerInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Maria Christina TsourlakisInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Andrea HinschInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Eike BurandtInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Waldemar WilczakInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Sarah MinnerInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Till S ClauditzInstitute of Pathology, University Medical Centre Hamburg-Eppendorf, Hamburg D-20246, Germany.
Universität Hamburg · DEUniversity Medical Center Hamburg-Eppendorf · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD8

Indexed as

CD8-Positive T-LymphocytesCell ProliferationColorectal NeoplasmsHumansInflammationKi-67 AntigenLymphoid TissuePhenotypeKi-67 AntigenCD8+ cytotoxic T cellscolorectal cancerlymphatic tissuetumor infiltrating lymphocytestumor microenvironment

Identifiers

PMID34083496
PMCPMC8221353
OpenAlexW3165235757

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.