ArticleFrontiers in immunology2021
Canonical Secretomes, Innate Immune Caspase-1-, 4/11-Gasdermin D Non-Canonical Secretomes and Exosomes May Contribute to Maintain Treg-Ness for Treg Immunosuppression, Tissue Repair and Modulate Anti-Tumor Immunity
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Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 25 citations in OpenAlex.
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- Novel Organelle-Based Intracellular Immunity with Mechanistic and Therapeutic Implications.Barrier immunity · 2026Article
- Chronic obstructive pulmonary disease reprograms the lung into an immune organ through trained immunity, cell death networks, and immune checkpoint dysregulation.Frontiers in medicine · 2026Article
- Discovery of Seven ROS-Sensitive Immune Checkpoints and 46 Ligands Mediating Immune Suppression Through T cell-APC Networks.Journal of Cancer · 2026Article
- Alzheimer's disease as an auto-innate immune pathology with potential cell trans-differentiation and enhanced trained immunity in 3xTg-AD mouse model.Journal of Alzheimer's disease : JAD · 2025Article
- Immune Checkpoints Are New Therapeutic Targets in Regulating Cardio-, and Cerebro-Vascular Diseases and CD4International journal of drug discovery and pharmacology · 2024Article
- Protein-rich foods, sea foods, and gut microbiota amplify immune responses in chronic diseases and cancers - Targeting PERK as a novel therapeutic strategy for chronic inflammatory diseases, neurodegenerative disorders, and cancer.Pharmacology & therapeutics · 2024Review
- Perspective: Pathological transdifferentiation-a novel therapeutic target for cardiovascular diseases and chronic inflammation.Frontiers in cardiovascular medicine · 2024Article
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- Cigarette Smoke Modulates Inflammation and ImmunityAntioxidants & redox signaling · 2023Review
- Protein expression/secretion boost by a novel unique 21-mer cis-regulatory motif (Exin21) via mRNA stabilization.Molecular therapy : the journal of the American Society of Gene Therapy · 2023Article
- Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways.JCI insight · 2023Article
- ROS regulation in gliomas: implications for treatment strategies.Frontiers in immunology · 2023Review
- Caspase-11 promotes high-fat diet-induced NAFLD by increasing glycolysis, OXPHOS, and pyroptosis in macrophages.Frontiers in immunology · 2023Article
- Innate immunity of vascular smooth muscle cells contributes to two-wave inflammation in atherosclerosis, twin-peak inflammation in aortic aneurysms and trans-differentiation potential into 25 cell types.Frontiers in immunology · 2023Article
- Cigarette Smoke and Morphine Promote Treg Plasticity to Th17 via Enhancing Trained Immunity.Cells · 2022Article
- Aorta in Pathologies May Function as an Immune Organ by Upregulating Secretomes for Immune and Vascular Cell Activation, Differentiation and Trans-Differentiation-Early Secretomes may Serve as Drivers for Trained Immunity.Frontiers in immunology · 2022Article
- Proline metabolism reprogramming of trained macrophages induced by early respiratory infection combined with allergen sensitization contributes to development of allergic asthma in childhood of mice.Frontiers in immunology · 2022Article
- Editorial: Highlights for Cardiovascular Therapeutics in 2021 - Trained Immunity, Immunometabolism, Gender Differences of Cardiovascular Diseases, and Novel Targets of Cardiovascular Therapeutics.Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
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Authors and funding
17 authors at 1 institution in 1 country.
Dong NiCenters for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
TingTing TangMetabolic Disease Research & Thrombosis Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Yifan LuCenters for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Keman XuCenters for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Ying ShaoCenters for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Fatma SaaoudCenters for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Jason SaredyMetabolic Disease Research & Thrombosis Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Lu LiuMetabolic Disease Research & Thrombosis Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Charles DrummerCenters for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Yu SunCenters for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Wenhui HuMetabolic Disease Research & Thrombosis Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Jahaira Lopez-PastranaDepartment of Psychiatry, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Jin J LuoDepartment of Neurology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Xiaohua JiangCenters for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Eric T ChoiDivision of Vascular and Endovascular Surgery, Department of Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Hong WangMetabolic Disease Research & Thrombosis Research, Department of Cardiovascular Sciences, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Xiaofeng YangCenters for Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, United States.
Temple University · US
Funding
CD4 T cell-targeted nanoparticle in vivo delivery of CRISPR/Cas9 genome editors for HIV cureR01AI145034 · NIAID · VIRGINIA COMMONWEALTH UNIVERSITY · PI HU, WENHUI · 2019 to 2023
$3.8MNIAID NIH HHS R01 AI145034
Abstract
We performed a transcriptomic analyses using the strategies we pioneered and made the following findings:
Indexed as
Immunity, InnateAnimalsBiomarkersCaspasesComputational BiologyDisease SusceptibilityExosomesGene Expression ProfilingGene Expression Regulation, EnzymologicGene Expression Regulation, NeoplasticHumansMiceModels, BiologicalNeoplasmsOrgan SpecificityReactive Oxygen SpeciesBiomarkersCaspasesReactive Oxygen Speciescanonical secretomeCD4+Foxp3+ regulatory T cells (Treg)immune checkpoint receptorsinnate immune caspase-1 dependent secretomeinnate immune caspase-4/11 dependent secretome
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.