Evidence map›Paper›PMID 34084887›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2021

The relationship of semantic intrusions to different etiological subtypes of MCI and cognitively healthy older adults.

Marcela Kitaigorodsky, Elizabeth Crocco, Rosie E Curiel-Cid, Giselle Leal, Diane Zheng, Melissa K Eustache, Maria T Greig-Custo, William Barker, Ranjan Duara, David A Loewenstein

Abstract read
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Cognitive dysfunction in women with theJournal of Alzheimer's disease : JAD · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. The importance of cognitive correlates of plasma amyloid-β 42/40.Journal of Alzheimer's disease : JAD · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Salient Cognitive Paradigms to Assess Preclinical Alzheimer's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marcela KitaigorodskyCenter for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences University of Miami Miller School of Medicine Miami USA.
Elizabeth CroccoCenter for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences University of Miami Miller School of Medicine Miami USA.
Rosie E Curiel-CidCenter for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences University of Miami Miller School of Medicine Miami USA.
Giselle LealCenter for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences University of Miami Miller School of Medicine Miami USA.
Diane ZhengCenter for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences University of Miami Miller School of Medicine Miami USA.
Melissa K EustacheCenter for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences University of Miami Miller School of Medicine Miami USA.
Maria T Greig-Custo1Florida Alzheimer's Disease Research Center Gainesville Florida USA.
William Barker1Florida Alzheimer's Disease Research Center Gainesville Florida USA.
Ranjan Duara1Florida Alzheimer's Disease Research Center Gainesville Florida USA.
David A LoewensteinCenter for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences University of Miami Miller School of Medicine Miami USA.

Funding

Social Determinants of Health, Race/Ethnicity, and White Matter HyperintensitiesP30AG066506 · NIA · UNIVERSITY OF FLORIDA · PI Ranjan Duara, DAVID LOEWENSTEIN · 2020 to 2026
$25.6M
A Novel Computerized Cognitive Stress Test Designed for Clinical Trials in Early Alzheimer's: Relationship with Multimodal Imaging Biomarkers in Diverse Cultural GroupsR01AG061106 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LOEWENSTEIN, DAVID · 2019 to 2023
$3.6M
Precision-based Assessment for the Detection of Mild Cognitive Impairment in Older AdultsR01AG055638 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CURIEL CID, ROSIE E · 2018 to 2022
$2.9M
Novel Detection of Early Cognitive and Functional Impairment in the ElderlyR01AG047649 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LOEWENSTEIN, DAVID · 2015 to 2019
$2.7M
NIA NIH HHS P30 AG066506NIA NIH HHS R01 AG047649NIA NIH HHS R01 AG055638NIA NIH HHS R01 AG061106
6 · The paper itself

Abstract

introductionThere is increasing evidence that susceptibility to proactive semantic interference (PSI) and the failure to recover from PSI (frPSI) as evidenced by intrusion errors may be early cognitive markers of both preclinical and prodromal Alzheimer's disease (AD).

methodsOne hundred forty-five participants were administered extensive clinical and neuropsychological evaluations including the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L), a sensitive cognitive stress test measuring PSI and frPSI. Participants also underwent structural magnetic resonance imaging (MRI) and amyloid positron emission tomography/computed tomography (PET/CT) imaging.

resultsPSI and frPSI errors were much more prevalent in the mild cognitive impairment (MCI)-AD (amyloid positive) group than the other diagnostic groups. The number of intrusion errors observed across the other MCI groups without amyloid pathology and those with normal cognition were comparable. DISCUSSION: Semantic intrusion errors on the LASSI-L occur much less frequently in persons who have different types of non-AD-related MCI and may be used as an early cognitive marker of prodromal AD.

Indexed as

Alzheimer's diseaseamyloidbiomarkerscognitive assessmentetiological subtypes of MCIIntrusion errorsmemorymild cognitive impairmentneuropsychological testssemantic interference

Identifiers

PMID34084887
PMCPMC8144934

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.