ArticleAmino acids2022
Protective effects of glycine against lipopolysaccharide-induced intestinal apoptosis and inflammation.
Article in Amino acids, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Article
- High dosage lipopolysaccharide-induced duodenal, cecal, hepatic, and cardiac inflammation, programmed cell death, permeability in chicken embryos models.Poultry science · 2025Article
- Immunomodulatory Effects of L-Arginine-Modified Silkworm Pupae Protein Enteral Nutrition on Murine Intestinal Morphology and Immunity.International journal of molecular sciences · 2025Article
- The Efficacy of Intratissue Percutaneous Electrolysis (EPIInternational journal of molecular sciences · 2024Article
- A first characterization of the microbiota-resilience link in swine.Microbiome · 2024Article
- Effect of Nutraceutical Factors on Hepatic Intermediary Metabolism in Wistar Rats with Induced Tendinopathy.International journal of molecular sciences · 2024Article
- Association of gut microbiota with lactose intolerance and coeliac disease: a two-sample Mendelian randomization study.Frontiers in nutrition · 2024Article
- New Insights of Biological Functions of Natural Polyphenols in Inflammatory Intestinal Diseases.International journal of molecular sciences · 2023Review
- Rice bran oil supplementation protects swine weanlings against diarrhea and lipopolysaccharide challenge.Journal of Zhejiang University. Science. B · 2023Article
- Tryptophan oxidation in young children with environmental enteric dysfunction classified by the lactulose rhamnose ratio.The American journal of clinical nutrition · 2022Article
- Dietary amino acids and intestinal microbiota.Amino acids · 2022Article
- Article
- Increased Ingestion of Hydroxy-Methionine by Both Sows and Piglets Improves the Ability of the Progeny to Counteract LPS-Induced Hepatic and Splenic Injury with Potential Regulation of TLR4 and NOD Signaling.Antioxidants (Basel, Switzerland) · 2022Article
- Article
- Effects of electroacupuncture on urinary metabolome and microbiota in presenilin1/2 conditional double knockout mice.Frontiers in microbiology · 2022Article
- Glycinergic Signaling in Macrophages and Its Application in Macrophage-Associated Diseases.Frontiers in immunology · 2021Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Intestinal dysfunction is commonly observed in humans and animals. Glycine (Gly) is a functional amino acid with anti-inflammatory and anti-apoptotic properties. The objective of this study was to test the protective effects of Gly against lipopolysaccharide (LPS)-induced intestinal injury. 28 C57BL/6 mice with a body weight (BW) of 18 ± 2 g were randomly assigned into four groups: CON (control), GLY (orally administered Gly, 5 g/kg BW/day for 6 days), LPS (5 mg/kg BW on day 7, i. p.), and GLY + LPS (Gly pretreatment and LPS administration). Histological alterations, inflammatory responses, epithelial cell apoptosis, and changes of the intestinal microbiota were analyzed. Results showed that, compared with the CON group, mice in the LPS treatment group showed decreased villus height, increased crypt depth, and decreased ratio of villus height to crypt depth, which were significantly attenuated by Gly. Neither LPS nor Gly treatment altered morphology of the distal colon tissues. LPS increased the apoptosis of jejunum and colon epithelial cells and protein abundance of cleaved caspase3 in the jejunum, which were markedly abrogated by Gly. LPS also elevated the mRNA levels of Toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MYD88), pro-inflammatory cytokines, and chemokines in the jejunum and colon. These alterations were significantly suppressed by Gly. In addition, Gly supplementation attenuated infiltration of CD4
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.