Evidence map›Paper›PMID 34085157›Full record

ArticleAmino acids2021

Proline oxidase silencing inhibits p53-dependent apoptosis in MCF-7 breast cancer cells.

Ilona Oscilowska, Thi Y L Huynh, Weronika Baszanowska, Izabela Prokop, Arkadiusz Surazynski, Mauro Galli, Piotr Zabielski, Jerzy Palka

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Amino acids, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. The Multifaceted Roles of Proline in Cell Behavior.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ilona OscilowskaDepartment of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222, Bialystok, Poland.ORCID http://orcid.org/0000-0002-7934-6973
Thi Y L HuynhDepartment of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222, Bialystok, Poland.ORCID http://orcid.org/0000-0001-9133-8186
Weronika BaszanowskaDepartment of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222, Bialystok, Poland.
Izabela ProkopDepartment of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222, Bialystok, Poland.ORCID http://orcid.org/0000-0001-6045-0394
Arkadiusz SurazynskiDepartment of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222, Bialystok, Poland.ORCID http://orcid.org/0000-0003-4475-873X
Mauro GalliDepartment of Medical Biology, Medical University of Bialystok, Mickiewicza 2C, 15-222, Bialystok, Poland.ORCID http://orcid.org/0000-0003-3871-8125
Piotr ZabielskiDepartment of Medical Biology, Medical University of Bialystok, Mickiewicza 2C, 15-222, Bialystok, Poland.ORCID http://orcid.org/0000-0002-4901-5217
Jerzy PalkaDepartment of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-222, Bialystok, Poland. pal@umb.edu.pl.ORCID http://orcid.org/0000-0002-8476-2023
Medical University of Białystok · PL

Funding

H2020 Marie Skłodowska-Curie Actions 754432Narodowe Centrum Nauki 2017/25/B/NZ7/02183Narodowe Centrum Nauki 2017/27/N/NZ7/01770
6 · The paper itself

Abstract

Proline oxidase (POX) is mitochondrial proline-degrading enzyme of dual apoptosis/survival function. POX expression and proline availability are considered an underlying mechanism for differential POX functions. The mechanism for POX-dependent regulation of cell death/survival was studied in wild-type (MCF-7

Indexed as

ApoptosisBreast NeoplasmsCell DeathCell Line, TumorCell SurvivalFemaleHumansMCF-7 CellsProlineProline OxidaseProteomicsReactive Oxygen SpeciesRNA, Small InterferingSignal TransductionTumor Suppressor Protein p53ProlineProline OxidaseReactive Oxygen SpeciesRNA, Small InterferingTP53 protein, humanTumor Suppressor Protein p53ApoptosisMCF-7 breast cancer cellsp53ProlineProline dehydrogenaseProline oxidase

Identifiers

PMID34085157
PMCPMC8651586
OpenAlexW3164654414

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.