Evidence map›Paper›PMID 34085182›Full record

ArticleMolecular neurobiology2021

The Carbonic Anhydrase Inhibitor E7070 Sensitizes Glioblastoma Cells to Radio- and Chemotherapy and Reduces Tumor Growth.

Silvia A Teixeira, Mariano S Viapiano, Augusto F Andrade, Mohan S Nandhu, Julia A Pezuk, Lucas T Bidinotto, Veridiana K Suazo, Luciano Neder, Carlos G Carlotti, Aline P Becker and 2 more

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In one paragraph

Article in Molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Recent progress in small molecules targeting the acidic tumor microenvironment.Journal of enzyme inhibition and medicinal chemistry · 2026
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  5. AnJournal of the Royal Society, Interface · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Silvia A TeixeiraDepartment of Paediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. sateixeira@usp.br.ORCID http://orcid.org/0000-0002-2462-8535
Mariano S ViapianoDepartment of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Augusto F AndradeDepartment of Human Genetics, McGill University, Montreal, QC, Canada.
Mohan S NandhuDepartment of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Julia A PezukDepartment of Genetics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Lucas T BidinottoMolecular Oncology Research Center, Barretos Cancer Hospital, Pio XII Foundation, Rua Antenor Duarte Villela, 1331, Barretos, SP, 14784-400, Brazil.
Veridiana K SuazoDepartment of Paediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Luciano NederMolecular Oncology Research Center, Barretos Cancer Hospital, Pio XII Foundation, Rua Antenor Duarte Villela, 1331, Barretos, SP, 14784-400, Brazil.
Carlos G CarlottiDepartment of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Aline P BeckerDepartment of Radiation Oncology, The Ohio State University, Columbus, OH, USA.
Luiz Gonzaga ToneDepartment of Paediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Carlos A ScrideliDepartment of Paediatrics, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Universidade de São Paulo · BRBrigham and Women's Hospital · USCentro Universitário da Fundação Educacional de Barretos · BRMcGill University · CAThe Ohio State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioblastomas (GBMs), the most common and lethal primary brain tumor, show inherent infiltrative nature and high molecular heterogeneity that make complete surgical resection unfeasible and unresponsive to conventional adjuvant therapy. Due to their fast growth rate even under hypoxic and acidic conditions, GBM cells can conserve the intracellular pH at physiological range by overexpressing membrane-bound carbonic anhydrases (CAs). The synthetic sulfonamide E7070 is a potent inhibitor of CAs that harbors putative anticancer properties; however, this drug has still not been tested in GBMs. The present study aimed to evaluate the effects of E7070 on CA9 and CA12 enzymes in GBM cells as well as in the tumor cell growth, migration, invasion, and resistance to radiotherapy and chemotherapy. We found that E7070 treatment significantly reduced tumor cell growth and increased radio- and chemotherapy efficacy against GBM cells under hypoxia. Our data suggests that E7070 has therapeutic potential as a radio-chemo-sensitizing in drug-resistant GBMs, representing an attractive strategy to improve the adjuvant therapy. We showed that CA9 and CA12 represent potentially valuable therapeutic targets that should be further investigated as useful diagnostic and prognostic biomarkers for GBM tailored therapy.

Indexed as

ApoptosisBrain NeoplasmsCarbonic Anhydrase InhibitorsCell CycleCell Line, TumorCell MovementCell ProliferationGlioblastomaHumansSulfonamidesCarbonic Anhydrase InhibitorsN-(3-chloro-7-indolyl)-1,4-benzenedisulphonamideSulfonamidesCarbonic anhydraseCell metabolismHypoxic microenvironmentPDX modelPH regulation

Identifiers

PMID34085182
OpenAlexW3165528810

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.