Evidence map›Paper›PMID 34087170›Full record

ArticleStructure (London, England : 1993)2021

A LINC between the nucleus and the cytoskeleton takes form(in).

Mark E Zweifel, Naomi Courtemanche

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Structure (London, England : 1993), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Mark E ZweifelDepartment of Genetics, Cell and Developmental Biology, University of Minnesota, Minneapolis, MN 55455, USA.
Naomi CourtemancheDepartment of Genetics, Cell and Developmental Biology, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: ncourtem@umn.edu.

Funding

Molecular mechanisms of bundled actin structure assembly by forminsR01GM122787 · NIGMS · UNIVERSITY OF MINNESOTA · PI Naomi Courtemanche · 2017 to 2026
$2.7M
NIGMS NIH HHS R01 GM122787
6 · The paper itself

Abstract

Dynamic nuclear positioning requires the formation of robust connections between the cytoskeleton and components of the LINC complex, a protein assembly that spans the nuclear envelope. A new study by Lim et al. (2021) reveals the mechanism of association between the LINC complex proteins Nesprin-1/2 Giant and the cytoplasmic formin FHOD1.

Indexed as

CytoskeletonNuclear ProteinsCell NucleusMicrotubulesNuclear EnvelopeNuclear Proteins

Identifiers

PMID34087170
PMCPMC8923135

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.