Evidence map›Paper›PMID 34088340›Full record

Trial reportArthritis research & therapy2021

Clinical risk factors associated with radiographic osteoarthritis progression among people with knee pain: a longitudinal study.

Milena Simic, Alison R Harmer, Maria Agaliotis, Lillias Nairn, Lisa Bridgett, Lyn March, Milana Votrubec, John Edmonds, Mark Woodward, Richard Day and 1 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Arthritis research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00513422 (The Effect of Glucosamine Sulphate on Structural Disease Progression in Knee Osteoarthritis and the Cost-effectiveness of Glucosamine Sulphate for Knee Arthritis.), which is not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00513422 phase4unknown statusnot on this map

The Effect of Glucosamine Sulphate on Structural Disease Progression in Knee Osteoarthritis and the Cost-effectiveness of Glucosamine Sulphate for Knee Arthritis.

TypeinterventionalSponsorUniversity of SydneyRan2007 to 2011Enrolled600ConditionsOsteoarthritis, KneeArmsGlucosamine sulphate and chondroitin, Glucosamine sulphate, Chondroitin sulphate, Placebo capsules for glucosamine and chondroitin
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

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  15. Heterologous production of chondroitin.Biotechnology reports (Amsterdam, Netherlands) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Milena SimicFaculty of Medicine and Health, Discipline of Physiotherapy, The University of Sydney, Sydney, Australia. milena.simic@sydney.edu.au.
Alison R HarmerFaculty of Medicine and Health, Discipline of Physiotherapy, The University of Sydney, Sydney, Australia.
Maria AgaliotisFaculty of Medicine and Health, Discipline of Physiotherapy, The University of Sydney, Sydney, Australia.
Lillias NairnFaculty of Medicine and Health, Discipline of Physiotherapy, The University of Sydney, Sydney, Australia.
Lisa BridgettFaculty of Medicine and Health, Discipline of Physiotherapy, The University of Sydney, Sydney, Australia.
Lyn MarchInstitute of Bone and Joint Research, The University of Sydney, Royal North Shore Hospital, Sydney, Australia.
Milana VotrubecGraduate School of Medicine, Notre Dame University, Sydney, Australia.
John EdmondsSt George Hospital Clinical School, University of New South Wales, Sydney, Australia.
Mark WoodwardThe George Institute for Global Health, University of New South Wales, Sydney, Australia.
Richard Day *Department of Clinical Pharmacology, St Vincent's Hospital, Sydney, Australia.ORCID 0000-0002-6045-6937
Marlene Fransen *Faculty of Medicine and Health, Discipline of Physiotherapy, The University of Sydney, Sydney, Australia.
The University of Sydney · AUUNSW Sydney · AUJohns Hopkins University · USThe University of Notre Dame Australia · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe aim of this study was to identify modifiable clinical factors associated with radiographic osteoarthritis progression over 1 to 2 years in people with painful medial knee osteoarthritis.

methodsA longitudinal study was conducted within a randomised controlled trial, the "Long-term Evaluation of Glucosamine Sulfate" (LEGS study). Recruitment occurred in 2007-2009, with 1- and 2-year follow-up assessments by blinded assessors. Community-dwelling people with chronic knee pain (≥4/10) and medial tibiofemoral narrowing (but retaining >2mm medial joint space width) on radiographs were recruited. From 605 participants, follow-up data were available for 498 (82%, mean [sd] age 60 [8] years). Risk factors evaluated at baseline were pain, physical function, use of non-steroidal anti-inflammatory drugs (NSAIDs), statin use, not meeting physical activity guidelines, presence of Heberden's nodes, history of knee surgery/trauma, and manual occupation. Multivariable logistic regression analysis was conducted adjusting for age, sex, obesity, high blood pressure, allocation to glucosamine and chondroitin treatment, and baseline structural disease severity (Kellgren and Lawrence grade, joint space width, and varus alignment). Radiographic osteoarthritis progression was defined as joint space narrowing ≥0.5mm over 1 to 2 years (latest follow-up used where available).

resultsRadiographic osteoarthritis progression occurred in 58 participants (12%). Clinical factors independently associated with radiographic progression were the use of NSAIDs, adjusted odds ratios (OR) and 95% confidence intervals (CI) 2.05 (95% CI 1.1 to 3.8), and not meeting physical activity guidelines, OR 2.07 (95% CI 0.9 to 4.7).

conclusionsAmong people with mild radiographic knee osteoarthritis, people who use NSAIDs and/or do not meet physical activity guidelines have a greater risk of radiographic osteoarthritis progression.

trial registrationClinicalTrials.gov , NCT00513422 . This original study trial was registered a priori, on August 8, 2007. The current study hypothesis arose before inspection of the data.

Indexed as

Knee JointOsteoarthritis, KneeDisease ProgressionHumansLongitudinal StudiesMiddle AgedPainRisk FactorsDisease progressionEpidemiologyKnee osteoarthritisNon-steroidal anti-inflammatory drugsRisk factors

Identifiers

PMID34088340
PMCPMC8176608
OpenAlexW3164361154

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.