ArticleCurrent biology : CB2021
Gatekeeper function for Short stop at the ring canals of the Drosophila ovary.
Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 46 citations in OpenAlex.
- Complementary volume electron microscopy-based approaches reveal ultrastructural changes in germline intercellular bridges.Journal of cell science · 2026Article
- Bridges under construction: the dynamics of ring canal expansion during Drosophila oogenesis.Developmental biology · 2026Review
- AbioRxiv : the preprint server for biology · 2026Article
- The cytoskeleton regulates cytoophidium dynamics in Drosophila ovaries.Cell & bioscience · 2026Article
- To Be or Not to Be an Oocyte: Msps/XMAP215 Controls Oocyte Cell Fate in thebioRxiv : the preprint server for biology · 2026Article
- Spatially distinct FRL and Ena dependent actin networks coordinate nuclear positioning in Drosophila nurse cells.PLoS genetics · 2026Article
- PolyQ-Expansion of Ataxin-2 Disrupts Microtubule Stability and Impairs Axon Outgrowth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- The lipid droplet protein Jabba promotes actin remodeling downstream of prostaglandin signaling duringMolecular biology of the cell · 2025Article
- Sequential and independent probabilistic events regulate differential axon targeting during development in Drosophila melanogaster.Nature neuroscience · 2025Article
- 'Mitotic' kinesin-5 is a dynamic brake for axonal growth in Drosophila.Development (Cambridge, England) · 2025Article
- EB-SUN, a new microtubule plus-end tracking protein inMolecular biology of the cell · 2024Article
- EB-SUN, a New Microtubule Plus-End Tracking Protein inbioRxiv : the preprint server for biology · 2024Article
- Lineage-based scaling of germline intercellular bridges during oogenesis.Development (Cambridge, England) · 2024Article
- Essential Role of COPII Proteins in Maintaining the Contractile Ring Anchoring to the Plasma Membrane during Cytokinesis inInternational journal of molecular sciences · 2024Article
- The Shot CH1 domain recognises a distinct form of F-actin during Drosophila oocyte determination.Development (Cambridge, England) · 2024Article
- The Importance of the Position of the Nucleus inCells · 2024Review
- The dynamic duo of microtubule polymerase Mini spindles/XMAP215 and cytoplasmic dynein is essential for maintainingProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Article
- Go with the flow - bulk transport by molecular motors.Journal of cell science · 2023Review
- CRISPR-Cas9-Mediated Knock-In Approach to Insert the GFPMethods in molecular biology (Clifton, N.J.) · 2023Article
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3 authors at 1 institution in 1 country.
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Abstract
Growth of the Drosophila oocyte requires transport of cytoplasmic materials from the interconnected sister cells (nurse cells) through ring canals, the cytoplasmic bridges that remained open after incomplete germ cell division. Given the open nature of the ring canals, it is unclear how the direction of transport through the ring canal is controlled. In this work, we show that a single Drosophila spectraplakin Short stop (Shot) controls the direction of flow from nurse cells to the oocyte. Knockdown of shot changes the direction of transport through the ring canals from unidirectional (toward the oocyte) to bidirectional. After shot knockdown, the oocyte stops growing, resulting in a characteristic small oocyte phenotype. In agreement with this transport-directing function of Shot, we find that it is localized at the asymmetric actin baskets on the nurse cell side of the ring canals. In wild-type egg chambers, microtubules localized in the ring canals have uniform polarity (minus ends toward the oocyte), while in the absence of Shot, these microtubules have mixed polarity. Together, we propose that Shot functions as a gatekeeper directing transport from nurse cells to the oocyte via the organization of microtubule tracks to facilitate the transport driven by the minus-end-directed microtubule motor cytoplasmic dynein. VIDEO ABSTRACT.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.