ArticleCirculation research2021
Targeting the Microtubule EB1-CLASP2 Complex Modulates Na
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Article in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
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Who cites it
27 citing papers in PubMed, 36 citations in OpenAlex.
- Decreasing Microtubule Detyrosination Improves Cardiac Mechanics and Sodium Channel Function in Arrhythmogenic Cardiomyopathy.Circulation. Arrhythmia and electrophysiology · 2026Article
- Nanoscale organization in the cell membrane dynamically modulates the biophysics of voltage-gated sodium channels.Nature communications · 2026Article
- Spastin-mediated severing of glutamylated microtubules controls cardiomyocyte coupling.Nature cardiovascular research · 2026Article
- The NaV1.5 auxiliary subunit FGF13 modulates channels by regulating membrane cholesterol independent of channel binding.The Journal of clinical investigation · 2025Article
- Ion channel traffic jams: the significance of trafficking deficiency in long QT syndrome.Cell discovery · 2025Review
- A Rare Noncoding Enhancer Variant inCirculation · 2025Article
- Article
- Zebrafish as a Model System for Brugada Syndrome.Reviews in cardiovascular medicine · 2024Review
- Genetic background determines the severity of age-dependent cardiac structural abnormalities and arrhythmia susceptibility in Scn5a-1798insD mice.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Article
- Decreasing microtubule detyrosination modulates Nav1.5 subcellular distribution and restores sodium current in mdx cardiomyocytes.Cardiovascular research · 2024Article
- Engineered tissue geometry and Plakophilin-2 regulate electrophysiology of human iPSC-derived cardiomyocytes.APL bioengineering · 2024Article
- Persistent PKA activation redistributes NaV1.5 to the cell surface of adult rat ventricular myocytes.The Journal of general physiology · 2024Article
- The Role ofCirculation research · 2024Article
- Ion channel trafficking implications in heart failure.Frontiers in cardiovascular medicine · 2024Review
- The leading example of the Leducq Foundation.Nature cardiovascular research · 2024Article
- Advances in understanding of cardiac sodium channel structure/function and their relation to disease pathogenesis and treatment.Heart rhythm · 2024Article
- Analysis ofAnimals : an open access journal from MDPI · 2023Article
- Sodium channel subpopulations with distinct biophysical properties and subcellular localization enhance cardiac conduction.The Journal of general physiology · 2023Article
- Microtubule plus-end tracking proteins: novel modulators of cardiac sodium channels and arrhythmogenesis.Cardiovascular research · 2023Article
- The intercalated disc: a unique organelle for electromechanical synchrony in cardiomyocytes.Physiological reviews · 2023Review
Corrections and comments
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Authors and funding
26 authors at 10 institutions in 5 countries.
Gerard A MarchalDepartment of Experimental Cardiology, Amsterdam UMC - location AMC, The Netherlands (G.A.M., S.P., S.C., C.C.V., E.M.L., I.M., A.O.V., C.R.B., V.P., C.A.R.).
Mariam JouniDepartment of Pharmacology, University Feinberg School of Medicine, Chicago, IL (M.J., F.P., C.G.V., A.L.G., P.W.B.).
David Y ChiangBrigham and Women's Hospital and Harvard Medical School, Boston, MA (D.Y.C., C.A.M.).
Marta Pérez-HernándezDivision of Cardiology (M.P.-H., M.D.), NYU School of Medicine.
Svitlana PodliesnaDepartment of Experimental Cardiology, Amsterdam UMC - location AMC, The Netherlands (G.A.M., S.P., S.C., C.C.V., E.M.L., I.M., A.O.V., C.R.B., V.P., C.A.R.).
Nuo YuDepartment of Cell Biology, Erasmus Medical Centre Rotterdam, The Netherlands (N.Y., N.G.).
Simona CasiniDepartment of Experimental Cardiology, Amsterdam UMC - location AMC, The Netherlands (G.A.M., S.P., S.C., C.C.V., E.M.L., I.M., A.O.V., C.R.B., V.P., C.A.R.).
Franck PotetDepartment of Pharmacology, University Feinberg School of Medicine, Chicago, IL (M.J., F.P., C.G.V., A.L.G., P.W.B.).
Christiaan C VeermanDepartment of Experimental Cardiology, Amsterdam UMC - location AMC, The Netherlands (G.A.M., S.P., S.C., C.C.V., E.M.L., I.M., A.O.V., C.R.B., V.P., C.A.R.).
Mischa KlerkDepartment of Medical Biology, Amsterdam UMC - location AMC, The Netherlands (M.K., A.O.V.).
Elisabeth M LodderDepartment of Experimental Cardiology, Amsterdam UMC - location AMC, The Netherlands (G.A.M., S.P., S.C., C.C.V., E.M.L., I.M., A.O.V., C.R.B., V.P., C.A.R.).
Isabella MengarelliDepartment of Experimental Cardiology, Amsterdam UMC - location AMC, The Netherlands (G.A.M., S.P., S.C., C.C.V., E.M.L., I.M., A.O.V., C.R.B., V.P., C.A.R.).
Kaomei GuanInstitute of Pharmacology and Toxicology, Technische Universität Dresden, Germany (K.G.).
Carlos G VanoyeDepartment of Pharmacology, University Feinberg School of Medicine, Chicago, IL (M.J., F.P., C.G.V., A.L.G., P.W.B.).
Eli RothenbergDepartment of Biochemistry and Pharmacology (E.R.), NYU School of Medicine.
Flavien CharpentierUniversité de Nantes, CNRS, INSERM, l'institut du Thorax, Nantes, France (F.C., R.R., V.P.).
Richard RedonUniversité de Nantes, CNRS, INSERM, l'institut du Thorax, Nantes, France (F.C., R.R., V.P.).
Alfred L GeorgeDepartment of Pharmacology, University Feinberg School of Medicine, Chicago, IL (M.J., F.P., C.G.V., A.L.G., P.W.B.).
Arie O VerkerkDepartment of Experimental Cardiology, Amsterdam UMC - location AMC, The Netherlands (G.A.M., S.P., S.C., C.C.V., E.M.L., I.M., A.O.V., C.R.B., V.P., C.A.R.).
Connie R BezzinaDepartment of Experimental Cardiology, Amsterdam UMC - location AMC, The Netherlands (G.A.M., S.P., S.C., C.C.V., E.M.L., I.M., A.O.V., C.R.B., V.P., C.A.R.).
Calum A MacRaeBrigham and Women's Hospital and Harvard Medical School, Boston, MA (D.Y.C., C.A.M.).
Paul W BurridgeDepartment of Pharmacology, University Feinberg School of Medicine, Chicago, IL (M.J., F.P., C.G.V., A.L.G., P.W.B.).
Mario DelmarDivision of Cardiology (M.P.-H., M.D.), NYU School of Medicine.
Niels GaljartDepartment of Cell Biology, Erasmus Medical Centre Rotterdam, The Netherlands (N.Y., N.G.).
Vincent PorteroDepartment of Experimental Cardiology, Amsterdam UMC - location AMC, The Netherlands (G.A.M., S.P., S.C., C.C.V., E.M.L., I.M., A.O.V., C.R.B., V.P., C.A.R.).
Carol Ann RemmeDepartment of Experimental Cardiology, Amsterdam UMC - location AMC, The Netherlands (G.A.M., S.P., S.C., C.C.V., E.M.L., I.M., A.O.V., C.R.B., V.P., C.A.R.).
I.R.C.C.S. Oasi Maria SS · ITNorthwestern University · USCentre National de la Recherche Scientifique · FRBrigham and Women's Hospital · USErasmus MC · NLAmsterdam University Medical Centers · NLHudson Simulation Service · USNew York University · USRoth and Rau (Germany) · DETechnische Universität Dresden · DE
Funding
A Community Zebrafish Resource for Modeling GWAS BiologyR24OD017870 · OD · BRIGHAM AND WOMEN'S HOSPITAL · PI GOESSLING, WOLFRAM, MACRAE, CALUM A. · 2014 to 2021
$6.3MPartners Healthcare Training Program in Precision and Genomic MedicineT32HG010464 · NHGRI · MASSACHUSETTS GENERAL HOSPITAL · PI HEIDI L REHM, JORDAN W SMOLLER · 2019 to 2026
$3.1MNHGRI NIH HHS T32 HG010464NIH HHS R24 OD017870
Abstract
[Figure: see text].
Indexed as
Action PotentialsAnimalsArrhythmias, CardiacCells, CulturedGlycogen Synthase Kinase 3 betaHEK293 CellsHumansLoss of Function MutationMaleMiceMice, Inbred C57BLMicrotubule-Associated ProteinsMyocytes, CardiacNAV1.5 Voltage-Gated Sodium ChannelProtein TransportZebrafishCLASP2 protein, mouseEB1 protein, mouseGlycogen Synthase Kinase 3 betaMicrotubule-Associated ProteinsNAV1.5 Voltage-Gated Sodium ChannelScn5a protein, mouseelectrophysiologymicroscopymicrotubulemyocyte, cardiaczebrafish
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.