Evidence map›Paper›PMID 34093456›Full record

ArticleFrontiers in microbiology2021

Brittni M Woodall, John R Harp, William T Brewer, Eric D Tague, Shawn R Campagna, Elizabeth M Fozo

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Genomic insights intoFrontiers in veterinary science · 2026
    Article
  10. Gut · 2025
    Article
  11. Microbiology (Reading, England) · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Probing Glycerolipid Metabolism using a Caged Clickable Glycerol-3-Phosphate Probe.Chembiochem : a European journal of chemical biology · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Brittni M WoodallDepartment of Chemistry, University of Tennessee, Knoxville, Knoxville, TN, United States.
John R HarpDepartment of Microbiology, University of Tennessee, Knoxville, Knoxville, TN, United States.
William T BrewerDepartment of Microbiology, University of Tennessee, Knoxville, Knoxville, TN, United States.
Eric D TagueDepartment of Chemistry, University of Tennessee, Knoxville, Knoxville, TN, United States.
Shawn R CampagnaDepartment of Chemistry, University of Tennessee, Knoxville, Knoxville, TN, United States.
Elizabeth M FozoDepartment of Microbiology, University of Tennessee, Knoxville, Knoxville, TN, United States.
University of Tennessee at Knoxville · US

Funding

Membrane alterations and daptomycin toleranceR01AI116571 · NIAID · UNIVERSITY OF TENNESSEE KNOXVILLE · PI FOZO, ELIZABETH M. · 2016 to 2020
$1.7M
NIAID NIH HHS R01 AI116571
6 · The paper itself

Abstract

The bacterial lipid membrane, consisting both of fatty acid (acyl) tails and polar head groups, responds to changing conditions through alteration of either the acyl tails and/or head groups. This plasticity is critical for cell survival as it allows maintenance of both the protective nature of the membrane as well as functioning membrane protein complexes. Bacteria that live in fatty-acid rich environments, such as those found in the human host, can exploit host fatty acids to synthesize their own membranes, in turn, altering their physiology.

Indexed as

cardiolipinCLsdaptomycinlipidomelysyl-phosphatidylglycerolmprF2

Identifiers

PMID34093456
PMCPMC8177052
OpenAlexW3164890589

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.