Evidence map›Paper›PMID 34094598›Full record

ReviewMinimally invasive surgery2021

The "Dark Side" of Pneumoperitoneum and Laparoscopy.

Giuseppina Rosaria Umano, Giulia Delehaye, Carmine Noviello, Alfonso Papparella

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Minimally invasive surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07299656 (Outcome of Active Aspiration Versus Simple Compression to Remove Residual Gas From Abdominal Cavity in Reducing Pain After Laparoscopic Cholecystectomy), which is not on this map. Cited by 38 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07299656 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Outcome of Active Aspiration Versus Simple Compression to Remove Residual Gas From Abdominal Cavity in Reducing Pain After Laparoscopic Cholecystectomy

TypeinterventionalSponsorKing Edward Medical UniversityRan2025 to 2027Enrolled62ConditionsShoulder Pain, Abdominal Pain (AP)ArmsGroup A (Active Aspiration), simple compression
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Giuseppina Rosaria UmanoDepartment of Woman, Child, and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Largo Madonna Delle Grazie N. 1, Naples 8013, Italy.
Giulia DelehayeDepartment of Woman, Child, and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Largo Madonna Delle Grazie N. 1, Naples 8013, Italy.
Carmine NovielloDepartment of Woman, Child, and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Largo Madonna Delle Grazie N. 1, Naples 8013, Italy.
Alfonso PapparellaDepartment of Woman, Child, and General and Specialized Surgery, University of Campania Luigi Vanvitelli, Largo Madonna Delle Grazie N. 1, Naples 8013, Italy.ORCID https://orcid.org/0000-0003-3846-7872
University of Campania "Luigi Vanvitelli" · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Laparoscopic surgery has been one of the most common procedures for abdominal surgery at pediatric age during the last few decades as it has several advantages compared to laparotomy, such as shorter hospital stays, less pain, and better cosmetic results. However, it is associated with both local and systemic modifications. Recent evidence demonstrated that carbon dioxide pneumoperitoneum might be modulated in terms of pressure, duration, temperature, and humidity to mitigate and modulate these changes. The aim of this study is to review the current knowledge about animal and human models investigating pneumoperitoneum-related biological and histological impairment. In particular, pneumoperitoneum is associated with local and systemic inflammation, acidosis, oxidative stress, mesothelium lining abnormalities, and adhesion development. Animal studies reported that an increase in pressure and time and a decrease in humidity and temperature might enhance the rate of comorbidities. However, to date, few studies were conducted on humans; therefore, this research field should be further investigated to confirm in experimental models and humans how to improve laparoscopic procedures in the spirit of minimally invasive surgeries.

Identifiers

PMID34094598
PMCPMC8163537
OpenAlexW3165378172

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.