Evidence map›Paper›PMID 34095115›Full record

ArticleFrontiers in cell and developmental biology2021

Diagnostic Biomarker Hsa_circ_0126218 and Functioning Prediction in Peripheral Blood Monocular Cells of Female Patients With Major Depressive Disorder.

Tianyi Bu, Zhengxue Qiao, Wenbo Wang, Xiuxian Yang, Jiawei Zhou, Lu Chen, Jiarun Yang, Jia Xu, Yanping Ji, Yini Wang and 4 more

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In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Circular RNAs in Blood and Its Clinical Relevance.Advances in experimental medicine and biology · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Research Progress of circRNAs in Glioblastoma.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tianyi BuPsychology and Health Management Center, Harbin Medical University, Harbin, China.
Zhengxue QiaoPsychology and Health Management Center, Harbin Medical University, Harbin, China.
Wenbo WangPsychology and Health Management Center, Harbin Medical University, Harbin, China.
Xiuxian YangPsychology and Health Management Center, Harbin Medical University, Harbin, China.
Jiawei ZhouPsychology and Health Management Center, Harbin Medical University, Harbin, China.
Lu ChenDepartment of Endocrinology, Peking Union Medical College Hospital, Beijing, China.
Jiarun YangPsychology and Health Management Center, Harbin Medical University, Harbin, China.
Jia XuPsychotherapy Department, The First Psychiatric Hospital of Harbin, Harbin, China.
Yanping JiDepartment of Nursing, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Yini WangPsychology and Health Management Center, Harbin Medical University, Harbin, China.
Wenxin ZhangMedical Department, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Yanjie YangPsychology and Health Management Center, Harbin Medical University, Harbin, China.
Xiaohui QiuPsychology and Health Management Center, Harbin Medical University, Harbin, China.
Yunmiao YuPsychology and Health Management Center, Harbin Medical University, Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAlthough major depressive diroder (MDD) has brought huge burden and challenges to society globally, effective and accurate diagnoses and treatments remain inadequate. The pathogenesis that for women are more likely to suffer from depression than men needs to be excavated as well. The function of circRNAs in pathological process of depression has not been widely investigated. This study aims to explore potential diagnostic biomarker circRNA of female patients with MDD and to investigate its role in pathogenesis.

methodsFirst, an expression profile of circRNAs in the peripheral blood monocular cells of MDD patients and healthy peripherals were established based on high-throughput sequencing analysis. In addition, the top 10 differentially expressed circRNAs were quantified by quantitative real-time PCR to explore diagnostic biomarkers. To further investigate the function of biomarkers in the pathogenesis of MDD, bioinformatics analysis on downstream target genes of the biomarkers was carried out.

resultsThere is a mass of dysregulated circRNAs in PBMCs between female MDD patients and healthy controls. Among the top 10 differentially expressed circRNAs, hsa_circ_0126218 is more feasible as a diagnostic biomarker. The expression level of hsa_circ_0126218 displayed upregulation in patients with MDD and the area under the operating characteristic curve of hsa_circ_0126218 was 0.801 (95% CI 0.7226-0.8791,

conclusionhsa_circ_0126218 can be considered as a new female MDD biomarker, and the pathogenesis of female MDD by the downstream regulation of hsa_circ_0126218 has been predicted. These findings may help further improve the early detection, effective diagnosis, convenient monitoring of complications, precise treatment, and timely recurrence prevention of depression.

Indexed as

bioinformatics analysiscircular RNAdiagnostic biomarkerhigh throughput sequencingmajor depressive disorderperipheral blood mononuclear cells

Identifiers

PMID34095115
PMCPMC8174117

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.