Evidence map›Paper›PMID 34095301›Full record

ArticleBioMed research international2021

Gentiopicroside Produces Endothelium-Independent Vasodilation by Deactivating the PI3K/Akt/Rho-Kinase Pathway in Isolated Rat Thoracic Aorta.

Shangping Xing, Feifei Nong, Jialiang Qin, Huicai Huang, Ruoting Zhan, Weiwen Chen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Regulatory mechanisms of Gentiopicroside on human diseases: a brief review.Naunyn-Schmiedeberg's archives of pharmacology · 2024
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Shangping XingResearch Center of Chinese Herbal Resource Science and Engineering, Key Laboratory of Chinese Medicinal Resource from Lingnan, Ministry of Education, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.ORCID https://orcid.org/0000-0001-7252-7176
Feifei NongPi-Wei Institute, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.ORCID https://orcid.org/0000-0002-2306-0108
Jialiang QinResearch Center of Chinese Herbal Resource Science and Engineering, Key Laboratory of Chinese Medicinal Resource from Lingnan, Ministry of Education, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.ORCID https://orcid.org/0000-0002-6513-9447
Huicai HuangResearch Center of Chinese Herbal Resource Science and Engineering, Key Laboratory of Chinese Medicinal Resource from Lingnan, Ministry of Education, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.ORCID https://orcid.org/0000-0002-8813-1499
Ruoting ZhanResearch Center of Chinese Herbal Resource Science and Engineering, Key Laboratory of Chinese Medicinal Resource from Lingnan, Ministry of Education, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.ORCID https://orcid.org/0000-0003-2469-4812
Weiwen ChenResearch Center of Chinese Herbal Resource Science and Engineering, Key Laboratory of Chinese Medicinal Resource from Lingnan, Ministry of Education, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.ORCID https://orcid.org/0000-0002-2628-4254
Guangzhou University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gentiopicroside (GPS), a main active secoiridoid glucoside derived from the roots of perennial herbs in the

Indexed as

AnimalsAorta, ThoracicCalciumCalcium Channel BlockersCalcium ChannelsCalcium SignalingChinaEndothelium, VascularInositol 1,4,5-Trisphosphate ReceptorsIridoid GlucosidesMaleMyocytes, Smooth MusclePhenylephrinePhosphatidylinositol 3-KinasesPotassium ChlorideProto-Oncogene Proteins c-aktCalciumCalcium Channel BlockersCalcium ChannelsgentiopicrosideInositol 1,4,5-Trisphosphate ReceptorsIridoid GlucosidesPhenylephrinePhosphatidylinositol 3-KinasesPotassium ChlorideProto-Oncogene Proteins c-aktrho-Associated KinasesRyanodine Receptor Calcium Release ChannelVasodilator Agents

Identifiers

PMID34095301
PMCPMC8140822
OpenAlexW3163762340

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.