Evidence map›Paper›PMID 34097027›Full record

ArticleEuropean heart journal. Cardiovascular Imaging2022

Comprehensive echocardiographic evaluation of the right heart in patients with pulmonary vascular diseases: the PVDOMICS experience.

Christine L Jellis, Margaret M Park, Aiden Abidov, Barry A Borlaug, Evan L Brittain, Robert Frantz, Paul M Hassoun, Evelyn M Horn, Wael A Jaber, Kim Jiwon and 12 more

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in European heart journal. Cardiovascular Imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04071327 (Pulmonary Hypertension Association Registry), which is not on this map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04071327 recruitingnot on this map

Pulmonary Hypertension Association Registry

Typeobservational_patient_registrySponsorPulmonary Hypertension Association, Inc.Ran2015 to 2025Enrolled3,000ConditionsPulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension, Pulmonary Hypertension
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
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  11. Article
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  13. Article
  14. It's All About That Right Ventricle.Journal of the American Heart Association · 2024
    Article
  15. Observational
  16. Observational
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  18. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 10 institutions in 1 country.

Christine L JellisDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.ORCID 0000-0002-8610-0533
Margaret M ParkDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Aiden AbidovWayne State University, 4646 John R Street, Detroit, MI 48201USA.
Barry A BorlaugDepartment of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55902USA.
Evan L BrittainVanderbilt University Medical Center and Vanderbilt Translational and Clinical Cardiovascular Research Center 2525 West End Avenue, Suite 300A, Nashville, TN 37203 USA.
Robert FrantzDepartment of Cardiovascular Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55902USA.
Paul M HassounDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 1830 E. Monument St, Room 540, Baltimore, MD 21205USA.
Evelyn M HornWeill Cornell Medicine, Division of Cardiology, 520 East 70th Street, Starr 443, New York, NY 10021USA.
Wael A JaberDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Kim JiwonWeill Cornell Medicine, Division of Cardiology, 520 East 70th Street, Starr 443, New York, NY 10021USA.
Maria G KarasWeill Cornell Medicine, Division of Cardiology, 520 East 70th Street, Starr 443, New York, NY 10021USA.ORCID 0000-0002-8763-6460
Deborah KwonDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Jane A LeopoldDivision of Cardiovascular Medicine, Brigham and Women's Hospital and Department of Cardiology, VA Boston Healthcare system, 77 Ave Louis Pasteur, NRB 0630-N, Boston MA 02115USA.
Bradley MaronDivision of Cardiovascular Medicine, Brigham and Women's Hospital and Department of Cardiology, VA Boston Healthcare system, 77 Ave Louis Pasteur, NRB 0630-N, Boston MA 02115USA.
Stephen C MathaiDepartment of Medicine, Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, 1830 E. Monument St, Room 540, Baltimore, MD 21205USA.
Reena MehraDepartment of Pulmonary Medicine, Respiratory Institute, Cleveland Clinic, 9500 Euclid Avenue Cleveland, OH 44195USA.
Franz RischardDepartment of Medicine, University of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724.
Erika B RosenzweigDivision of Pediatric Cardiology, Department of Pediatrics and Medicine, Columbia University Medical Center-New York Presbyterian Hospital, 3959 Broadway, New York, NY 10032USA.
W H Wilson TangDepartment of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Rebecca VanderpoolDepartment of Medicine, University of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724.
James D ThomasBluhm Cardiovascular Institute, Northwestern University, 676 N Saint Clair, Chicago Illinois 60611USA.
PVDOMICS Study Group
Cleveland Clinic · USCornell University · USBrigham and Women's Hospital · USJohns Hopkins University · USMayo Clinic · USUniversity of Arizona · USNewYork–Presbyterian Hospital · USNorthwestern University · USVanderbilt University Medical Center · USWayne State University · US

Funding

Pulmonary Vascular Disease Phenomics Program (PVDOMICS) Data Coordinating CenterU01HL125177 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BECK, GERALD J, ERZURUM, SERPIL C. · 2014 to 2020
$20.0M
Clinical, Genetic, and Proteomic Risk Factors for Pulmonary Hypertension in Heart FailureR01HL146588 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BRITTAIN, EVAN L, FREIBERG, MATTHEW S · 2019 to 2022
$3.4M
Intergrated Endothelial Phenotyping to Redefine Pulmonary HypertensionU01HL125215 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LEOPOLD, JANE A, WAXMAN, AARON B · 2014 to 2018
$1.7M
NHLBI NIH HHS U01 HL125177NHLBI NIH HHS U01 HL125215
6 · The paper itself

Abstract

aimsThere is a wide spectrum of diseases associated with pulmonary hypertension, pulmonary vascular remodelling, and right ventricular dysfunction. The NIH-sponsored PVDOMICS network seeks to perform comprehensive clinical phenotyping and endophenotyping across these disorders to further evaluate and define pulmonary vascular disease. METHODS AND

resultsEchocardiography represents the primary non-invasive method to phenotype cardiac anatomy, function, and haemodynamics in these complex patients. However, comprehensive right heart evaluation requires the use of multiple echocardiographic parameters and optimized techniques to ensure optimal image acquisition. The PVDOMICS echo protocol outlines the best practice approach to echo phenotypic assessment of the right heart/pulmonary artery unit.

conclusionNovel workflow processes, methods for quality control, data for feasibility of measurements, and reproducibility of right heart parameters derived from this study provide a benchmark frame of reference. Lessons learned from this protocol will serve as a best practice guide for echocardiographic image acquisition and analysis across the spectrum of right heart/pulmonary vascular disease.

Indexed as

Hypertension, PulmonaryVentricular Dysfunction, RightEchocardiographyHeartHumansReproducibility of ResultsVentricular Function, Rightechocardiographyfractional area changepulmonary hypertensionright ventriclestrainTAPSE

Identifiers

PMID34097027
PMCPMC9212349
OpenAlexW3167144233

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.