ArticleDevelopment (Cambridge, England)2021
Piecemeal regulation of convergent neuronal lineages by bHLH transcription factors in Caenorhabditis elegans.
Article in Development (Cambridge, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Single-cell transcriptomic profiling of C. elegans Q neuroblast lineage during migration and differentiation.PloS one · 2026Article
- Regulation of motor neuron differentiation in thebioRxiv : the preprint server for biology · 2025Article
- A gene expression atlas of a juvenile nervous system.bioRxiv : the preprint server for biology · 2025Article
- Single-cell transcriptomic profiling ofbioRxiv : the preprint server for biology · 2025Article
- Induction of host genes by nested genes duringiScience · 2025Article
- Functional analysis of conserved C. elegans bHLH family members uncovers lifespan control by a peptidergic hub neuron.PLoS biology · 2025Article
- Neurogenesis in Caenorhabditis elegans.Genetics · 2024Review
- Functional analysis of conservedbioRxiv : the preprint server for biology · 2024Article
- A full-body transcription factor expression atlas with completely resolved cell identities in C. elegans.Nature communications · 2024Article
- The CCAAT-box transcription factor, NF-Y complex, mediates the specification of the IL1 neurons in C. elegans.BMB reports · 2023Article
- Cell-specific effects of the sole C. elegans Daughterless/E protein homolog, HLH-2, on nervous system development.Development (Cambridge, England) · 2023Article
- Widespread employment of conserved C. elegans homeobox genes in neuronal identity specification.PLoS genetics · 2022Article
- Article
- Joint actions of diverse transcription factor families establish neuron-type identities and promote enhancer selectivity.Genome research · 2022Article
- Transcriptional regulation of neuronal identity.The European journal of neuroscience · 2022Review
- Open Frontiers in Neural Cell Type Investigations; Lessons FromFrontiers in neuroscience · 2021Review
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Authors and funding
4 authors.
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Abstract
Cells of the same type can be generated by distinct cellular lineages that originate in different parts of the developing embryo ('lineage convergence'). Several Caenorhabditis elegans neuron classes composed of left/right or radially symmetric class members display such lineage convergence. We show here that the C. elegans Atonal homolog lin-32 is differentially expressed in neuronal lineages that give rise to left/right or radially symmetric class members. Loss of lin-32 results in the selective loss of the expression of pan-neuronal markers and terminal selector-type transcription factors that confer neuron class-specific features. Another basic helix-loop-helix (bHLH) gene, the Achaete-Scute homolog hlh-14, is expressed in a mirror image pattern relative to lin-32 and is required to induce neuronal identity and terminal selector expression on the contralateral side of the animal. These findings demonstrate that distinct lineage histories converge via different bHLH factors at the level of induction of terminal selector identity determinants, which thus serve as integrators of distinct lineage histories. We also describe neuron-to-neuron identity transformations in lin-32 mutants, which we propose to also be the result of misregulation of terminal selector gene expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.