Evidence map›Paper›PMID 34101350›Full record

ArticleJournal of diabetes investigation2021

Epidemiology, genetic landscape and classification of childhood diabetes mellitus in the State of Qatar.

Basma Haris, Saras Saraswathi, Sara Al-Khawaga, Reem Hasnah, Amira Saeed, Shihab Mundekkadan, Noor Hamed, Houda Afyouni, Tasneem Abdel-Karim, Shayma Mohammed and 9 more

Open access · goldAbstract read
In one paragraph

Article in Journal of diabetes investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Type 2 Diabetes Mellitus in a 7 Year Old Girl.International medical case reports journal · 2022
    Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Basma HarisDivision of Endocrinology, Department of Pediatrics, Sidra Medicine, Doha, Qatar.
Saras SaraswathiDivision of Endocrinology, Department of Pediatrics, Sidra Medicine, Doha, Qatar.
Sara Al-KhawagaDivision of Endocrinology, Department of Pediatrics, Sidra Medicine, Doha, Qatar.
Reem HasnahTranslational Research, Sidra Medicine, Doha, Qatar.
Amira SaeedTranslational Research, Sidra Medicine, Doha, Qatar.
Shihab MundekkadanDivision of Endocrinology, Department of Pediatrics, Sidra Medicine, Doha, Qatar.
Noor HamedDivision of Endocrinology, Department of Pediatrics, Sidra Medicine, Doha, Qatar.
Houda AfyouniDivision of Endocrinology, Department of Pediatrics, Sidra Medicine, Doha, Qatar.
Tasneem Abdel-KarimDivision of Endocrinology, Department of Pediatrics, Sidra Medicine, Doha, Qatar.
Shayma MohammedDivision of Endocrinology, Department of Pediatrics, Sidra Medicine, Doha, Qatar.
Amel KhalifaDivision of Endocrinology, Department of Pediatrics, Sidra Medicine, Doha, Qatar.
Maryam Al-MaadheedDivision of Endocrinology, Department of Pediatrics, Sidra Medicine, Doha, Qatar.
Mahmoud Al-ZyoudDivision of Endocrinology, Department of Pediatrics, Sidra Medicine, Doha, Qatar.
Ahmed ShamekhDivision of Endocrinology, Department of Pediatrics, Sidra Medicine, Doha, Qatar.
Ahmed ElawwaDivision of Endocrinology, Department of Pediatrics, Sidra Medicine, Doha, Qatar.
Fawziya Al-KhalafDivision of Endocrinology, Department of Pediatrics, Sidra Medicine, Doha, Qatar.
Sabri BoughorbelTranslational Research, Sidra Medicine, Doha, Qatar.
Goran PetrovskiDivision of Endocrinology, Department of Pediatrics, Sidra Medicine, Doha, Qatar.
Khalid HussainDivision of Endocrinology, Department of Pediatrics, Sidra Medicine, Doha, Qatar.ORCID https://orcid.org/0000-0002-5480-7112
Qatar Airways (Qatar) · QA

Funding

Qatar National Research Fund QNRF-NPRP 10-6100017-AXX
6 · The paper itself

Abstract

AIMS/

introductionTo study the epidemiology, genetic landscape and causes of childhood diabetes mellitus in the State of Qatar. MATERIALS AND

methodsAll patients (aged 0-18 years) with diabetes mellitus underwent biochemical, immunological and genetic testing. American Diabetes Association guidelines were used to classify types of diabetes mellitus. The incidence and prevalence of all the different types of diabetes mellitus were calculated.

resultsTotal number of children with diabetes mellitus was 1,325 (type 1 n = 1,096, ≥1 antibody; type 2 n = 104, type 1B n = 53; maturity onset diabetes of the young n = 20; monogenic autoimmune n = 4; neonatal diabetes mellitus n = 10;, syndromic diabetes mellitus n = 23; and double diabetes mellitus n = 15). The incidence and prevalence of type 1 diabetes were 38.05 and 249.73 per 100,000, respectively, and for type 2 were 2.51 and 23.7 per 100,000, respectively. The incidence of neonatal diabetes mellitus was 34.4 per 1,000,000 live births, and in indigenous Qataris the incidence was 43.6 per 1,000,000 live births. The prevalence of type 1 diabetes and type 2 diabetes in Qatari children was double compared with other nationalities. The prevalence of maturity onset diabetes of the young in Qatar was 4.56 per 100,000.

conclusionsThis is the first prospective and comprehensive study to document the epidemiology and genetic landscape of childhood diabetes mellitus in this region. Qatar has the fourth highest incidence of type 1 diabetes mellitus, with the incidence and prevalence being higher in Qatari compared with non-Qatari. The prevalence of type 2 diabetes mellitus is also higher in Qatar than in Western countries. The incidence of neonatal diabetes mellitus is the second highest in the world. GCK is the most common form of maturity onset diabetes of the young, and a large number of patients have type 1B diabetes mellitus.

Indexed as

AdolescentChildChild, PreschoolDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleHumansIncidenceInfantInfant, NewbornMalePrevalenceProspective StudiesQatarEpidemiologyPediatric diabetesType 1 diabetes

Identifiers

PMID34101350
PMCPMC8668069
OpenAlexW3169965114

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.