Evidence map›Paper›PMID 34102857›Full record

Trial reportCirculation. Cardiovascular imaging2021

Positron Emission Tomography Imaging of Regional Versus Global Myocardial Sympathetic Activity to Improve Risk Stratification in Patients With Ischemic Cardiomyopathy.

Jason G E Zelt, Jean Zhuo Wang, Lisa M Mielniczuk, Rob S B Beanlands, James A Fallavollita, John M Canty, Robert A deKemp

Registry-linked trialOpen access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation. Cardiovascular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01400334 (Hibernating Myocardium and Sudden Cardiac Death), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01400334 completednot on this map

Hibernating Myocardium and Sudden Cardiac Death

TypeobservationalSponsorState University of New York at BuffaloRan2004 to 2012Enrolled257ConditionsIschemic Cardiomyopathy, Hibernating Myocardium, Nerve, Disorder, SympatheticArmsPositron Emission Tomography
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. PET imaging of cardiac sympathetic nervous system dysfunction using meta-[European journal of nuclear medicine and molecular imaging · 2026
    Article
  3. Review
  4. Imaging of cardiac sympathetic dysfunction with 18F-FDOPA PET/CT in patients with heart failure: a pilot study.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  5. Review
  6. Usefulness of the Vall d'Hebron Risk Score to stratify the risk of patients with ischemic cardiomyopathy.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Jason G E Zelt *Department of Medicine (Cardiology), University of Ottawa Heart Institute, Canada (J.G.E.Z., J.Z.W., L.M.M., R.S.B.B., R.A.dk.).
Jean Zhuo Wang *Department of Medicine (Cardiology), University of Ottawa Heart Institute, Canada (J.G.E.Z., J.Z.W., L.M.M., R.S.B.B., R.A.dk.).
Lisa M MielniczukDepartment of Medicine (Cardiology), University of Ottawa Heart Institute, Canada (J.G.E.Z., J.Z.W., L.M.M., R.S.B.B., R.A.dk.).
Rob S B BeanlandsDepartment of Medicine (Cardiology), University of Ottawa Heart Institute, Canada (J.G.E.Z., J.Z.W., L.M.M., R.S.B.B., R.A.dk.).
James A FallavollitaVA Western New York Healthcare System, Buffalo, NY (J.A.F., J.M.C.).
John M CantyVA Western New York Healthcare System, Buffalo, NY (J.A.F., J.M.C.).
Robert A deKempDepartment of Medicine (Cardiology), University of Ottawa Heart Institute, Canada (J.G.E.Z., J.Z.W., L.M.M., R.S.B.B., R.A.dk.).
University of Ottawa · CAVA Western New York Healthcare System · US

Funding

University of Buffalo Clinical and Translational Science Institute - Supplement SchulyerUL1TR001412 · NCATS · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI MURPHY, TIMOTHY F · 2015 to 2024
$33.8M
PAREPET II_Prediction of ARrhythnic Events with Positron Emission Tomography IIR01HL130266 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI CANTY, JOHN M, FALLAVOLLITA, JAMES · 2016 to 2022
$3.6M
Hibernating Myocardium and Sudden Cardiac DeathR01HL076252 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI CANTY, JOHN M · 2004 to 2008
$3.3M
NCATS NIH HHS UL1 TR001412NHLBI NIH HHS R01 HL076252NHLBI NIH HHS R01 HL130266
6 · The paper itself

Abstract

backgroundCurrent risk assessment approaches fail to identify the majority of patients at risk of sudden cardiac arrest (SCA). Noninvasive imaging of the cardiac sympathetic nervous system using single-photon emission computed tomography and positron emission tomography offers the potential for refining SCA risk assessment. While various [

methodsIn a post hoc competing-risks analysis of the PAREPET trial (Prediction of Arrhythmic Events With Positron Emission Tomography), we compared global innervation and regional denervation parameters using the norepinephrine analog [

resultsDuring a median follow-up of 4.2 years, there were 56 cardiac-related deaths, of which 26 were SCAs. For any given regional denervation volume, there was substantial heterogeneity in global innervation scores. Global retention index and distribution volume did not decrease until regional defects exceeded 40% left ventricle. Global scale parameters, retention index, and distribution volume (area under the curve=0.61,

conclusionsRegional denervation volume has superior cause-specific mortality prediction for SCA versus global parameters of sympathetic innervation. These results have widespread implications for future cardiac sympathetic imaging, which will greatly simplify innervation analysis. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT01400334.

Indexed as

AgedCardiomyopathiesFemaleHumansMaleMyocardial IschemiaPositron-Emission TomographyPrognosisSympathetic Nervous SystemVentricular Function, Leftdeathdenervationpositron emission tomographyradioisotopessympathetic nervous system

Identifiers

PMID34102857
PMCPMC8208501
OpenAlexW3169668620

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.