Evidence map›Paper›PMID 34107771›Full record

Trial reportAIDS research and human retroviruses2022

Short Communication: Persistence of HIV After Allogeneic Bone Marrow Transplant in a Dually Infected Individual.

Adam A Capoferri, Andrew D Redd, Christopher D Gocke, Laura R Clark, Richard F Ambinder, Christine M Durand

Registry-linked trialOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AIDS research and human retroviruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01836068 (Optimized Antiretroviral Therapy During Allogeneic Hematopoietic Stem Cell Transplantation in HIV-1-infected Individuals), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01836068 early_phase1completednot on this map

Optimized Antiretroviral Therapy During Allogeneic Hematopoietic Stem Cell Transplantation in HIV-1-infected Individuals

TypeinterventionalSponsorSidney Kimmel Comprehensive Cancer Center at Johns HopkinsRan2013 to 2021Enrolled11ConditionsHIVArmsEnfuvirtide
3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Adam A CapoferriSchool of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.ORCID 0000-0002-6048-2115
Andrew D ReddSchool of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Christopher D GockeSidney Kimmel Cancer Center, Baltimore, Maryland, USA.
Laura R ClarkSchool of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Richard F AmbinderSidney Kimmel Cancer Center, Baltimore, Maryland, USA.
Christine M DurandSchool of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
Johns Hopkins University · USSidney Kimmel Cancer Center · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN KEITH MEEKER · 1985 to 2026
$208.6M
Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Anna Palmer Durbin · 2012 to 2026
$67.0M
TUMOR VACCINESP01CA015396 · NCI · JOHNS HOPKINS UNIVERSITY · PI HESS, ALLAN D · 1985 to 2016
$38.1M
International Studies of the Acquired Immune Deficiency Syndrome (AIDS)ZIAAI000361 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REDD, ANDREW · 2009 to 2025
$15.8M
Targeting MRDP01CA225618 · NCI · JOHNS HOPKINS UNIVERSITY · PI Lukasz Pawel Gondek · 2019 to 2026
$15.1M
Optimal Antiretroviral Therapy During Bone Marrow Transplant in HIV-1 InfectionK23CA177321 · NCI · JOHNS HOPKINS UNIVERSITY · PI DURAND, CHRISTINE MARIE · 2014 to 2018
$808k
NCI NIH HHS K23 CA177321NCI NIH HHS P01 CA015396NCI NIH HHS P01 CA225618NCI NIH HHS P30 CA006973NIAID NIH HHS P30 AI094189
6 · The paper itself

Abstract

Allogeneic bone marrow transplant (alloBMT) with continuous antiretroviral therapy alone has not been shown to completely eradicate HIV, possibly due to HIV persistence in rare residual host cells or infection of donor cells. Within a trial of alloBMT in individuals with hematological malignancies and HIV (ClinicalTrials.gov, NCT01836068), we measured HIV reservoirs longitudinally using a quantitative viral outgrowth assay. We sequenced the reverse transcriptase region of

Indexed as

Hematopoietic Stem Cell TransplantationHIV InfectionsAnti-Retroviral AgentsBone Marrow TransplantationCD4-Positive T-LymphocytesHumansPhylogenyViral LoadAnti-Retroviral Agentsallogeneic bone marrow transplantdual infectionHIV latent reservoirHIV persistence

Identifiers

PMID34107771
PMCPMC8817692
OpenAlexW3171308238

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.