Evidence map›Paper›PMID 34110370›Full record

ReviewBiochemical Society transactions2021

Bacteria autoaggregation: how and why bacteria stick together.

El-Shama Q A Nwoko, Iruka N Okeke

Open access · hybridAbstract readReview
In one paragraph

Review in Biochemical Society transactions, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 103 citations in OpenAlex.

  1. Article
  2. Review
  3. Morphogenesis of bacterial colonies in liquid crystalline environments.Proceedings of the National Academy of Sciences of the United States of America · 2026
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  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Protozoan Communities and Their Contribution to Predation onEnvironmental science & technology · 2025
    Article
  14. Article
  15. Synergistic probiotic consortium ofVeterinary world · 2025
    Article
  16. Inhibitory effects of berberine againstMicrobiology spectrum · 2025
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

El-Shama Q A NwokoDepartment of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Ibadan, Oyo State, Nigeria.ORCID 0000-0003-1082-660X
Iruka N OkekeDepartment of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Ibadan, Oyo State, Nigeria.ORCID 0000-0002-1694-7587
University of Ibadan · NG

Funding

Medical Research Council MR/L00464X/1
6 · The paper itself

Abstract

Autoaggregation, adherence between identical bacterial cells, is important for colonization, kin and kind recognition, and survival of bacteria. It is directly mediated by specific interactions between proteins or organelles on the surfaces of interacting cells or indirectly by the presence of secreted macromolecules such as eDNA and exopolysaccharides. Some autoaggregation effectors are self-associating and present interesting paradigms for protein interaction. Autoaggregation can be beneficial or deleterious at specific times and niches. It is, therefore, typically regulated through transcriptional or post-transcriptional mechanisms or epigenetically by phase variation. Autoaggregation can contribute to bacterial adherence, biofilm formation or other higher-level functions. However, autoaggregation is only required for these phenotypes in some bacteria. Thus, autoaggregation should be detected, studied and measured independently using both qualitative and quantitative in vitro and ex vivo methods. If better understood, autoaggregation holds the potential for the discovery of new therapeutic targets that could be cost-effectively exploited.

Indexed as

BacteriaBacterial AdhesionBacterial ProteinsBacterial Secretion SystemsBiofilmsGene Expression Regulation, BacterialMembrane ProteinsMicrobial ViabilityPhase VariationProtein BindingBacterial ProteinsBacterial Secretion SystemsMembrane Proteinsadherenceautoaggregationbiofilmself-associating

Identifiers

PMID34110370
PMCPMC8286834
OpenAlexW3171694985

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.