Evidence map›Paper›PMID 34114148›Full record

ArticleMolecular and cellular biochemistry2021

Ticagrelor alleviates high-carbohydrate intake induced altered electrical activity of ventricular cardiomyocytes by regulating sarcoplasmic reticulum-mitochondria miscommunication.

Yusuf Olgar, Aysegul Durak, Sinan Degirmenci, Erkan Tuncay, Deniz Billur, Semir Ozdemir, Belma Turan

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Yusuf OlgarFaculty of Medicine, Department of Biophysics, Ankara University, Ankara, Turkey.
Aysegul DurakFaculty of Medicine, Department of Biophysics, Ankara University, Ankara, Turkey.
Sinan DegirmenciFaculty of Medicine, Department of Biophysics, Ankara University, Ankara, Turkey.
Erkan TuncayFaculty of Medicine, Department of Biophysics, Ankara University, Ankara, Turkey.
Deniz BillurFaculty of Medicine, Department of Histology and Embryology, Ankara University, Ankara, Turkey.
Semir OzdemirFaculty of Medicine, Department of Biophysics, Akdeniz University, Antalya, Turkey. osemir@akdeniz.edu.tr.
Belma TuranFaculty of Medicine, Department of Biophysics, Ankara University, Ankara, Turkey. belma.turan@medicine.ankara.edu.tr.ORCID http://orcid.org/0000-0003-2583-9294
Ankara University · TRAkdeniz University · TR

Funding

Türkiye Bilimsel ve Teknolojik Araştirma Kurumu SBAG-216S979
6 · The paper itself

Abstract

Metabolic syndrome (MetS) is associated with additional cardiovascular risk in mammalians while there are relationships between hyperglycemia-associated cardiovascular dysfunction and increased platelet P2Y12 receptor activation. Although P2Y12 receptor antagonist ticagrelor (Tica) plays roles in reduction of cardiovascular events, its beneficial mechanism remains poorly understood. Therefore, we aimed to clarify whether Tica can exert a direct protective effect in ventricular cardiomyocytes from high-carbohydrate diet-induced MetS rats, at least, through affecting sarcoplasmic reticulum (SR)-mitochondria (Mit) miscommunication. Tica treatment of MetS rats (150 mg/kg/day for 15 days) significantly reversed the altered parameters of action potentials by reversing sarcolemmal ionic currents carried by voltage-dependent Na

Indexed as

Action PotentialsAnimalsDietary CarbohydratesIon TransportMaleMetabolic SyndromeMitochondria, HeartMyocytes, CardiacRatsRats, WistarSarcoplasmic ReticulumSignal TransductionTicagrelorDietary CarbohydratesTicagrelorArrhythmiaElectrical activityHeart dysfunctionInsulin resistanceMetabolic syndromeMitochondriaOxidative stressSarcoplasmic reticulum

Identifiers

PMID34114148
OpenAlexW3167493364

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.