Evidence map›Paper›PMID 34115759›Full record

ArticlePLoS genetics2021

DYF-4 regulates patched-related/DAF-6-mediated sensory compartment formation in C. elegans.

Hui Hong, Huicheng Chen, Yuxia Zhang, Zhimao Wu, Yingying Zhang, Yingyi Zhang, Zeng Hu, Jian V Zhang, Kun Ling, Jinghua Hu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PLoS genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Glia Development and Function in the NematodeCold Spring Harbor perspectives in biology · 2024
    Review
  4. Meta-Analysis ofFrontiers in microbiology · 2022
    Article
  5. Journal of developmental biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hui HongCAS Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.ORCID 0000-0002-7238-1709
Huicheng ChenCAS Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.
Yuxia ZhangDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America.
Zhimao WuCAS Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.
Yingying ZhangCAS Key Laboratory of Insect Developmental and Evolutionary Biology, CAS Center for Excellence in Molecular Plant Sciences, Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, China.
Yingyi ZhangDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America.
Zeng HuDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America.
Jian V ZhangCenter for Energy Metabolism and Reproduction, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences (CAS), Shenzhen, China.
Kun LingDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America.
Jinghua HuDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America.
Qing WeiCenter for Energy Metabolism and Reproduction, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences (CAS), Shenzhen, China.ORCID 0000-0001-7803-1139

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coordination of neurite extension with surrounding glia development is critical for neuronal function, but the underlying molecular mechanisms remain poorly understood. Through a genome-wide mutagenesis screen in C. elegans, we identified dyf-4 and daf-6 as two mutants sharing similar defects in dendrite extension. DAF-6 encodes a glia-specific patched-related membrane protein that plays vital roles in glial morphogenesis. We cloned dyf-4 and found that DYF-4 encodes a glia-secreted protein. Further investigations revealed that DYF-4 interacts with DAF-6 and functions in a same pathway as DAF-6 to regulate sensory compartment formation. Furthermore, we demonstrated that reported glial suppressors of daf-6 could also restore dendrite elongation and ciliogenesis in both dyf-4 and daf-6 mutants. Collectively, our data reveal that DYF-4 is a regulator for DAF-6 which promotes the proper formation of the glial channel and indirectly affects neurite extension and ciliogenesis.

Indexed as

Genome, HelminthAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell CommunicationCiliaCloning, MolecularEscherichia coliGene ExpressionGene Expression Regulation, DevelopmentalGenetic VectorsIntracellular Signaling Peptides and ProteinsMutagenesisNerve Tissue ProteinsNeuritesNeurogenesisCaenorhabditis elegans ProteinsDAF-6 protein, C elegansIntracellular Signaling Peptides and ProteinsNerve Tissue ProteinsRecombinant Proteins

Identifiers

PMID34115759
PMCPMC8221789

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.