Evidence map›Paper›PMID 34116647›Full record

SynthesisBMC infectious diseases2021

COVID-19 and gastrointestinal symptoms in Mexico, a systematic review: does location matter?

Antonio Pizuorno, Nora A Fierro, Edgar D Copado-Villagrana, María E Herrera-Solís, Gholamreza Oskrochi, Hassan Brim, Hassan Ashktorab

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in BMC infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. A Comprehensive Meta-Analysis of COVID-19 in Latin America.SOJ microbiology & infectious diseases · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Antonio PizuornoLa Universidad del Zulia, Faculty of Medicine, School of Medicine, Maracaibo, Zulia state, 4002, Venezuela.
Nora A FierroDepartment of Immunology, Institute of Biomedical Research, National Autonomous University of Mexico, Ciudad University, CP 04510, Mexico City, Mexico.
Edgar D Copado-VillagranaMexican Social Security Institute, Guadalajara, Mexico.
María E Herrera-SolísMexican Social Security Institute, Guadalajara, Mexico.
Gholamreza OskrochiCollege of Engineering and Technology, American University of the Middle East, Egaila, Kuwait.
Hassan BrimDepartment of Medicine, Department of Pathology and Cancer Center, Department of Biochemistry & Molecular Biology, Howard University College of Medicine, 2041 Georgia Avenue, N.W, Washington, D.C, 20060, USA.
Hassan AshktorabDepartment of Medicine, Department of Pathology and Cancer Center, Department of Biochemistry & Molecular Biology, Howard University College of Medicine, 2041 Georgia Avenue, N.W, Washington, D.C, 20060, USA. hashktorab@howard.edu.ORCID http://orcid.org/0000-0002-4048-4666
Howard University · USMexican Social Security Institute · MXAmerican University of the Middle East · KWUniversidad del Zulia · VEUniversidad Nacional Autónoma de México · MX

Funding

Sleep Disorders in Adults with Sickle Cell Disease: Frequency, Associations with Cardiovascular and Pain Indicators, and Responses to TreatmentU54MD007597 · NIMHD · HOWARD UNIVERSITY · PI William M. Southerland · 2019 to 2026
$37.7M
PROTEOMICS CORE FACILITYG12MD007597 · NIMHD · HOWARD UNIVERSITY · PI SOUTHERLAND, WILLIAM M. · 2012 to 2018
$14.8M
NIH HHS G12MD007597NIMHD NIH HHS G12 MD007597NIMHD NIH HHS U54 MD007597
6 · The paper itself

Abstract

backgroundCovid-19 in Mexico is on the rise in different parts of the country. We aimed to study the symptoms and comorbidities that associate with this pandemic in 3 different regions of Mexico.

methodsWe analyzed data from SARS-CoV-2 positive patients evaluated at healthcare centers and hospitals of Mexico (n = 1607) including Northwest Mexico (Sinaloa state), Southeast Mexico (Veracruz state) and West Mexico (Jalisco state) between March 1 and July 30, 2020. Mexico consists of a total population that exceeds 128 million. Demographics, comorbidities and clinical symptoms were collected. Statistical descriptive analysis and correlation analyses of symptoms, comorbidities and mortality were performed.

resultsA total of 1607 hospitalized patients positive for COVID-19 across all 3 regions of Mexico were included. The average age was 54.6 years and 60.4% were male. A mortality rate of 33.1% was observed. The most common comorbidities were hypertension (43.2%), obesity (30.3%) and diabetes (31.4%). Hypertension was more frequent in West (45%), followed by Northwest (37%) and Southeast Mexico (29%). Obesity was around 30% in Northwest and West whereas an 18% was reported in Southeast. Diabetes was most common in West (34%) followed by Northwest (22%) and Southeast (13%). This might be related to the highest mortality rate in Northwest (31%) and West (37%) when compared to Southeast. Most common symptoms in our overall cohort were fever (80.8%), cough (79.8%), headache (66%), dyspnea (71.1%), myalgia (53.8%), joints pain (50.8%) and odynophagia (34.8%). Diarrhea was the main gastrointestinal (GI) symptom (21.3%), followed by abdominal pain (18%), and nausea/ vomiting (4.5%). Diarrhea and abdominal pain were more common in West (23.1 and 21%), followed by Southeast (17.8, and 9.8%) and Northwest (11.4 and 3.1%).

conclusionOur study showed a high mortality rate likely related to high frequencies of comorbidities (hypertension, obesity and diabetes). Mortality was different across regions. These discrepancies might be related to the differences in the frequencies of comorbidities, and partially attributed to differences in socio-economic conditions and quality of care. Thus, our findings stress the need for improved strategies to get better outcomes in our population.

Indexed as

COVID-19Gastrointestinal DiseasesComorbidityDiabetes MellitusFemaleHumansHypertensionMaleMexicoMiddle AgedObesitySARS-CoV-2Coronavirus disease-19DiarrheaGastrointestinal manifestationMexicoPandemic

Identifiers

PMID34116647
PMCPMC8193163
OpenAlexW3166494949

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.