Evidence map›Paper›PMID 34117245›Full record

ArticleNature communications2021

Evidence of the interplay of genetics and culture in Ethiopia.

Saioa López, Ayele Tarekegn, Gavin Band, Lucy van Dorp, Nancy Bird, Sam Morris, Tamiru Oljira, Ephrem Mekonnen, Endashaw Bekele, Roger Blench and 3 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
27.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  4. Sudan's complex genetic admixture history drives adaptation to malaria in Sudanese Copts.Proceedings of the National Academy of Sciences of the United States of America · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Saioa López *Research Department of Genetics, Evolution & Environment, University College London, London, UK. saioa.lopez@ucl.ac.uk.ORCID http://orcid.org/0000-0003-2936-4070
Ayele Tarekegn *Department of Archaeology and Heritage Management, College of Social Sciences, Addis Ababa University, New Classrooms (NCR) Building, Second Floor, Office No. 214, Addis Ababa University, Addis Ababa, Ethiopia. ayele.tarekegn@aau.edu.et.
Gavin BandWellcome Centre for Human Genetics, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-1710-9024
Lucy van DorpResearch Department of Genetics, Evolution & Environment, University College London, London, UK.ORCID http://orcid.org/0000-0002-6211-2310
Nancy BirdResearch Department of Genetics, Evolution & Environment, University College London, London, UK.ORCID http://orcid.org/0000-0003-2596-874X
Sam MorrisResearch Department of Genetics, Evolution & Environment, University College London, London, UK.
Tamiru OljiraGenomics & Bioinformatics Research Directorate (GBRD), Ethiopian Biotechnology Institute (EBTi), Addis Ababa, Ethiopia.ORCID http://orcid.org/0000-0002-8186-1667
Ephrem MekonnenInstitute of Biotechnology, Addis Ababa University, Addis Ababa, Ethiopia.ORCID http://orcid.org/0000-0003-0416-649X
Endashaw BekeleCollege of Natural and Computational Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Roger BlenchMcDonald Institute for Archaeological Research, University of Cambridge, Cambridge, UK.
Mark G ThomasResearch Department of Genetics, Evolution & Environment, University College London, London, UK.ORCID http://orcid.org/0000-0002-2452-981X
Neil BradmanHenry Stewart Group, London, UK.
Garrett HellenthalResearch Department of Genetics, Evolution & Environment, University College London, London, UK. g.hellenthal@ucl.ac.uk.ORCID http://orcid.org/0000-0002-5760-8020
University College London · GBAddis Ababa University · ETCentre for Human Genetics · GBThe London College · GBUniversity College Hospital · GBUniversity of Jos · NG

Funding

Biotechnology and Biological Sciences Research Council BB/L009382/1Biotechnology and Biological Sciences Research Council BB/R01356X/1Department of HealthWellcome TrustWellcome Trust 098386/Z/12/ZWellcome Trust 204911/Z/16/Z
6 · The paper itself

Abstract

The rich linguistic, ethnic and cultural diversity of Ethiopia provides an unprecedented opportunity to understand the level to which cultural factors correlate with-and shape-genetic structure in human populations. Using primarily new genetic variation data covering 1,214 Ethiopians representing 68 different ethnic groups, together with information on individuals' birthplaces, linguistic/religious practices and 31 cultural practices, we disentangle the effects of geographic distance, elevation, and social factors on the genetic structure of Ethiopians today. We provide evidence of associations between social behaviours and genetic differences among present-day peoples. We show that genetic similarity is broadly associated with linguistic affiliation, but also identify pronounced genetic similarity among groups from disparate language classifications that may in part be attributable to recent intermixing. We also illustrate how groups reporting the same culture traits are more genetically similar on average and show evidence of recent intermixing, suggesting that shared cultural traits may promote admixture. In addition to providing insights into the genetic structure and history of Ethiopia, we identify the most important cultural and geographic predictors of genetic differentiation and provide a resource for designing sampling protocols for future genetic studies involving Ethiopians.

Indexed as

Genetics, PopulationBlack PeopleCultural DiversityEthiopiaEthnicityFemaleGenetic VariationHaplotypesHumansLanguageLinguisticsMaleMultigene FamilyReligionSocial Factors

Identifiers

PMID34117245
PMCPMC8196081
OpenAlexW3170574268

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.