Evidence map›Paper›PMID 34120271›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022

ApoE4-positive multiple sclerosis patients are more likely to have cognitive impairment: a cross-sectional study.

Farshid Mashayekhi, Saeed Sadigh-Eteghad, Amirreza Naseri, Milad Asadi, Negin Abbasi Garravnd, Mahnaz Talebi

Abstract read
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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Cognitive impairment in multiple sclerosis: from phenomenology to neurobiological mechanisms.Journal of neural transmission (Vienna, Austria : 1996) · 2024
    Review
  7. Review
  8. APOE4 Status and Cognitive Function in Middle-aged and Elderly People.Balkan journal of medical genetics : BJMG · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Farshid MashayekhiNeurosciences Research Center (NSRC), Tabriz University of Medical Sciences, 5166614756, Tabriz, Iran.
Saeed Sadigh-EteghadNeurosciences Research Center (NSRC), Tabriz University of Medical Sciences, 5166614756, Tabriz, Iran.ORCID http://orcid.org/0000-0003-2872-1072
Amirreza NaseriStudent Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.ORCID http://orcid.org/0000-0001-9723-0109
Milad AsadiImmunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Negin Abbasi GarravndFaculty of Educational Sciences and Psychology, University of Tabriz, Tabriz, Iran.ORCID http://orcid.org/0000-0002-3168-1297
Mahnaz TalebiNeurosciences Research Center (NSRC), Tabriz University of Medical Sciences, 5166614756, Tabriz, Iran. Talebi511@yahoo.com.ORCID http://orcid.org/0000-0002-7613-3913
Tabriz University of Medical Sciences · IRUniversity of Tabriz · IR

Funding

Cognitive Sciences and Technologies Council Registration code: 8205Tabriz University of Medical Science Registration code: 62855
6 · The paper itself

Abstract

backgroundMultiple sclerosis (MS) presents with a wide variety of symptoms, including cognitive dysfunction. Previous studies in terms of the possible function of the ApoE4 allele as a risk factor for cognitive dysfunction in MS patients were associated with conflicting results. The role of the ε4 isoform of apolipoprotein (ApoE4) was investigated in this study as a risk factor for cognitive dysfunction in MS patients.

methodsMildly disabled relapsing-remitting MS (RRMS) patients were involved in this study. The neurocognitive assessment is conducted by the Minimal Assessment of Cognitive Function in MS (MACFIMS) battery. After determining the genotype, patients were divided into two groups of ApoE4-positive and ApoE4-negative groups, and cognitive findings were compared.

resultsSeventy-one patients with a mean age of 31.43 ± 8.75 were involved in this study. Eleven out of 17 (64.70%) patients in the ApoE4-positive group had at least one impaired test, while this rate was 16 out of 54 (29.62%) in the ApoE4-negative group (p < 0.01). The rate of overall cognitive impairment (failure in ≥ 2 tests) was not statistically different between groups of the study (p = 0.75). Impairment in Paced Auditory Serial Addition Test (PASAT) task and also the mean score of Brief Visuospatial Memory Test-Revised (BVMT-R) tests were different between two groups (p = 0.01 and 0.02, respectively).

conclusionMS ApoE4-positive patients are more likely to have at least one impaired cognitive test, but there is a need for more studies with larger sample sizes and based on MS-specific cognitive tests to confirm these findings.

Indexed as

Cognitive DysfunctionMultiple SclerosisMultiple Sclerosis, Relapsing-RemittingAdultApolipoproteinsCognitionCross-Sectional StudiesHumansNeuropsychological TestsYoung AdultApolipoproteinsApoE4ApolipoproteinCognitionCognitive impairmentMultiple sclerosis

Identifiers

PMID34120271
OpenAlexW3167254967

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.